https://scholars.lib.ntu.edu.tw/handle/123456789/463651
標題: | Application of the University of pennsylvania smell identification test (Traditional Chinese Version) for detecting olfactory deficits in early Parkinson's disease in a Taiwanese cohort | 作者: | Yu C.-Y RUEY-MEEI WU |
公開日期: | 2014 | 卷: | 4 | 期: | 2 | 起(迄)頁: | 175-180 | 來源出版物: | Journal of Parkinson's Disease | 摘要: | Background: Olfactory dysfunction is a non-motor feature of Parkinson's disease (PD) that appears at an early stage. The University of Pennsylvania Smell Identification Test (UPSIT) is the most widely used test for olfactory dysfunction, with multiple language versions available, including one in Traditional Chinese (UPSIT-TC). However, the UPSIT-TC has rarely been applied to the elderly population or patients with PD in Taiwan. Objective: The present study aimed to establish normative data in a Taiwanese cohort and evaluate the efficacy of the UPSIT-TC for detecting olfactory deficits in early PD. Methods: The UPSIT-TC was administered to 161 healthy Taiwanese subjects divided into four age groups: 40-49, 50-59, 60-69, and 70-79 years. Furthermore, 30 patients with PD with less than 2 years disease duration were examined with the UPSIT-TC. Results: The normative data from this cohort were lower than expected, deviating from North American norms by 2.5 to 5 points. The deviation was more prominent with advanced age. The PD group had a significantly lower mean UPSIT-TC score than the age-and gender-matched control group (p < 0.0001). With a cutoff score of 29.5, the sensitivity and specificity of the UPSIT-TC for the diagnosis of olfactory dysfunction in early PD was 86% and 70%, respectively. The subjects with PD, advanced age, and shorter education had significantly lower UPSIT-TC scores (p < 0.0001). Conclusions: The UPSIT-TC effectively detected hyposmia in early PD in the Taiwanese cohort. Despite the modification of UPSIT-TC items, a discrepancy was found between the Taiwanese and North American norms. ? 2014-IOS Press. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463651 | ISSN: | 1877-7171 | DOI: | 10.3233/JPD-130309 | SDG/關鍵字: | adult; age distribution; aged; article; clinical article; clinical effectiveness; cohort analysis; controlled study; diagnostic test; diagnostic test accuracy study; disease course; disease duration; ethnic group; female; human; hyposmia; male; middle aged; predictive value; priority journal; sensitivity and specificity; sex difference; smelling disorder; Taiwanese; University of Pennsylvania Smell Identification Test in Traditional Chinese; age; complication; neuropsychological test; Olfaction Disorders; Parkinson disease; smelling; Taiwan; very elderly; Adult; Age Factors; Aged; Aged, 80 and over; Cohort Studies; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Olfaction Disorders; Olfactory Perception; Parkinson Disease; Taiwan |
顯示於: | 醫學系 |
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