https://scholars.lib.ntu.edu.tw/handle/123456789/463652
Title: | HIV-associated parkinsonism reversed with antiretroviral therapy | Authors: | Cheng Y.-W CHIN-HSIEN LIN RUEY-MEEI WU |
Issue Date: | 2014 | Journal Volume: | 19 | Journal Issue: | 2 | Start page/Pages: | 199-203 | Source: | Neurology Asia | Abstract: | Human immunodeficiency virus (HIV) infection can cause variable movement disorders, including parkinsonism. HIV-related parkinsonism usually responds well to highly-active antiretroviral therapy (HAART), suggesting a possible reversible dysfunction of the dopaminergic system. We report the case of a 42-year-old man who presented with rapidly progressive symmetric parkinsonism, cognitive decline, and loss of postural reflex as the initial manifestation of HIV infection. A significant improvement of his parkinsonism after HAART demonstrates a potentially reversible dopaminergic system dysfunction secondary to HIV infection. A normal 99mTc-TRODAT-1 SPECT image after HAART treatment paralleled the clinical improvement in extrapyramidal symptoms. Early identification of HIV-related parkinsonism, especially in patients with symmetrical akinetic-rigidity and early loss of posture reflex, is important for its potential reversibility with HAART therapy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463652 | ISSN: | 1823-6138 | SDG/Keyword: | antiretrovirus agent; immunoglobulin G; lamivudine; nevirapine; zidovudine; adult; article; case report; CD4 lymphocyte count; clinical feature; cognitive defect; disease association; heterosexuality; human; Human immunodeficiency virus infection; hyperreflexia; immunoglobulin production; male; mental health; Mini Mental State Examination; neurologic examination; nuclear magnetic resonance imaging; parkinsonism; protein cerebrospinal fluid level; treatment duration; Unified Parkinson Disease Rating Scale; unsteadiness; virus load; white matter lesion |
Appears in Collections: | 醫學系 |
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