https://scholars.lib.ntu.edu.tw/handle/123456789/463666
Title: | STX6 rs1411478 is not associated with increased risk of Parkinson's disease | Authors: | Trinh J Vilari?o-G?ell C Donald A Shah B Yu I Szu-Tu C Aasly J.O RUEY-MEEI WU Hentati F Rajput A.H Rajput A Farrer M.J. |
Issue Date: | 2013 | Journal Volume: | 19 | Journal Issue: | 5 | Start page/Pages: | 563-565 | Source: | Parkinsonism and Related Disorders | Abstract: | A variant in Syntaxin 6 (a soluble N-ethylmaleimide-sensitive factor attachment protein receptor STX6) (rs1411478) has been shown to be associated with progressive supranuclear palsy (PSP). Although Parkinson's disease (PD) and PSP are distinct neurodegenerative diseases, they share some clinical and genetic features. In this study, we evaluated STX6 genetic variability in PD susceptibility in ethnically matched case-control series from Canada, Norway, Taiwan and Tunisia and we evaluated the presence of pathogenic mutations within families. No pathogenic mutations were found in STX6. Similarly, statistical analysis of rs1411478 failed to identify differences in genotype or allelic frequencies between cases and controls. Our results do not support a role for STX6 in PD. ? 2013 Elsevier Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463666 | ISSN: | 1353-8020 | DOI: | 10.1016/j.parkreldis.2013.01.019 | SDG/Keyword: | syntaxin; syntaxin 6; unclassified drug; aged; article; Canada; case control study; controlled study; female; gene frequency; gene mutation; genetic risk; genetic susceptibility; genetic variability; genotype; human; major clinical study; male; Norway; Parkinson disease; priority journal; syntaxin 6 gene; Taiwan; Tunisia; Adult; Aged; Aged, 80 and over; Canada; Case-Control Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Norway; Parkinson Disease; Qa-SNARE Proteins; Risk Factors; Taiwan; Tunisia |
Appears in Collections: | 醫學系 |
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