https://scholars.lib.ntu.edu.tw/handle/123456789/463666
標題: | STX6 rs1411478 is not associated with increased risk of Parkinson's disease | 作者: | Trinh J Vilari?o-G?ell C Donald A Shah B Yu I Szu-Tu C Aasly J.O RUEY-MEEI WU Hentati F Rajput A.H Rajput A Farrer M.J. |
公開日期: | 2013 | 卷: | 19 | 期: | 5 | 起(迄)頁: | 563-565 | 來源出版物: | Parkinsonism and Related Disorders | 摘要: | A variant in Syntaxin 6 (a soluble N-ethylmaleimide-sensitive factor attachment protein receptor STX6) (rs1411478) has been shown to be associated with progressive supranuclear palsy (PSP). Although Parkinson's disease (PD) and PSP are distinct neurodegenerative diseases, they share some clinical and genetic features. In this study, we evaluated STX6 genetic variability in PD susceptibility in ethnically matched case-control series from Canada, Norway, Taiwan and Tunisia and we evaluated the presence of pathogenic mutations within families. No pathogenic mutations were found in STX6. Similarly, statistical analysis of rs1411478 failed to identify differences in genotype or allelic frequencies between cases and controls. Our results do not support a role for STX6 in PD. ? 2013 Elsevier Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463666 | ISSN: | 1353-8020 | DOI: | 10.1016/j.parkreldis.2013.01.019 | SDG/關鍵字: | syntaxin; syntaxin 6; unclassified drug; aged; article; Canada; case control study; controlled study; female; gene frequency; gene mutation; genetic risk; genetic susceptibility; genetic variability; genotype; human; major clinical study; male; Norway; Parkinson disease; priority journal; syntaxin 6 gene; Taiwan; Tunisia; Adult; Aged; Aged, 80 and over; Canada; Case-Control Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Norway; Parkinson Disease; Qa-SNARE Proteins; Risk Factors; Taiwan; Tunisia |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。