https://scholars.lib.ntu.edu.tw/handle/123456789/463722
標題: | Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease | 作者: | Fong C.-S RUEY-MEEI WU Shieh J.-C Chao Y.-T Fu Y.-P Kuao C.-L Cheng C.-W. |
公開日期: | 2007 | 卷: | 378 | 期: | 1-2 | 起(迄)頁: | 136-141 | 來源出版物: | Clinica Chimica Acta | 摘要: | Background: Hypothetic mechanism of the individual vulnerability to oxidative stress through metabolism of environmental xenobiotics and genotypic polymorphisms has been considered to promote the development of Parkinson's disease (PD). In this case-control study, we determined the role of manganese-containing superoxide dismutase (MnSOD) and NAD(P)H: quinone oxidoreductase 1 (NQO1) genes in PD risk in a population with high prevalence of pesticide exposure. Methods: From southwestern region of Taiwan, we enrolled 153 patients with idiopathic PD and 155 healthy control subjects matched for age, sex and origin. Detailed questionnaires of face-to-face interviews among these subjects were collected. PCR-based restriction fragment length polymorphism (RFLP) assays were used to determine the genotypes of MnSOD (- 9 T > C) and NQO1 (609 C > T) genes. Results: Exposure to pesticides associated with PD was significant among patients with an increased odds ratio (OR) of 1.69 (95%CI, 1.07-2.65), and this association remained significant after adjustment for age, sex, and cigarette smoking (aOR = 1.68, 95%CI, 1.03-2.76, P = 0.023). Considering genetic factors, there were no significant differences in frequencies of both genotypes of MnSOD and NQO1 polymorphisms between PD patients and the control subjects (P > 0.05). However, this difference in genotype distribution was significant among subjects who had been exposed to pesticide, with aOR of 2.49 (95%CI, 1.18-5.26, P = 0.0072) for MnSOD C allele and aOR of 2.42 (95%CI, 1.16-4.76, P = 0.0089) for NQO1 T allele, respectively. Moreover, among subjects exposed to pesticide, the combined MnSOD/NQO1 variant genotype was significantly associated with a 4.09-fold increased risk of PD (95%CI, 1.34-10.64, P = 0.0052). Conclusion: Susceptible variants of MnSOD and NQO1 genes may interact with occupational pesticide exposure to increase PD risk in southwestern Taiwanese. ? 2006 Elsevier B.V. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463722 | ISSN: | 0009-8981 | DOI: | 10.1016/j.cca.2006.11.006 | SDG/關鍵字: | manganese superoxide dismutase; oxidoreductase; pesticide; reduced nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1; unclassified drug; aged; allele; article; cigarette smoking; confidence interval; controlled study; ethnic and racial groups; female; gene; genetic polymorphism; genetic susceptibility; genetic variability; genotype; heredity; human; human cell; interview; major clinical study; male; occupational exposure; Parkinson disease; polymerase chain reaction; population; prevalence; priority journal; questionnaire; restriction fragment length polymorphism; risk; sex; statistical significance; Taiwan; Aged; Case-Control Studies; Environmental Exposure; Female; Genotype; Humans; Male; Middle Aged; NAD(P)H Dehydrogenase (Quinone); Parkinson Disease; Pesticides; Polymorphism, Genetic; Reactive Oxygen Species; Risk; Superoxide Dismutase |
顯示於: | 醫學系 |
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