https://scholars.lib.ntu.edu.tw/handle/123456789/463730
標題: | DNA haplotype analysis of CAG repeat in Taiwanese Huntington's disease patients | 作者: | Wang C.K. MING-JANG CHIU et al. WUH-LIANG HWU Chen C.M. Ro L.S. Chen S.T. Gwinn-Hardy K. Yang C.C. RUEY-MEEI WU TA-FU CHEN Wang H.C. Chao M.C. Chiu M.J. Lu C.J. Lee-Chen G.J. |
公開日期: | 2004 | 卷: | 52 | 期: | 2 | 起(迄)頁: | 96-100 | 來源出版物: | European Neurology | 摘要: | We studied the expanded CAG repeat and adjacent CCG repeat in 53 Huntington's disease (HD) patients and 172 unrelated normal subjects matched to the patients for ethnic origin. The range of the CAG repeat varied from 38 to 109 in the HD patients and from 10 to 29 in the control group. A significant negative correlation was found between the age at onset and the CAG expansion, with no significant influence of the adjacent CCG repeat on the age at onset by multiple regression analysis. Allelic association using CCG repeat and 2 flanking dinucleotide repeat markers within 150 kb of the HD gene revealed linkage disequilibrium for 2 of 3 markers. Haplotype analysis of 24 HD families using these markers identified 3 major haplotypes underlying 87.5% of HD chromosomes. The data suggested frequent haplotypes in the Taiwanese population on which one or more mutational events leading to the disease occurred. Copyright ? 2004 S. Karger AG, Basel. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463730 | ISSN: | 0014-3022 | DOI: | 10.1159/000079938 | SDG/關鍵字: | allele; article; chromosome; correlation analysis; DNA determination; DNA flanking region; ethnology; family; gene linkage disequilibrium; gene mutation; haplotype; Huntington chorea; multiple regression; nucleotide repeat; onset age; priority journal; Taiwan; Alleles; Case-Control Studies; Chi-Square Distribution; Chromosomes; Family Health; Haplotypes; Humans; Huntington Disease; Linkage Disequilibrium; Mutation; Polymerase Chain Reaction; Taiwan; Trinucleotide Repeats |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。