https://scholars.lib.ntu.edu.tw/handle/123456789/463738
標題: | Monitoring of the levodopa concentration-response relationship in Parkinson's disease | 作者: | RUEY-MEEI WU CHUN-HWEI TAI Chen R.-C. |
公開日期: | 2000 | 卷: | 16 | 期: | 3 | 起(迄)頁: | 117-125 | 來源出版物: | Kaohsiung Journal of Medical Sciences | 摘要: | Motor fluctuations and abnormal involuntary movements are common complications encountered in advanced Parkinson's disease (PD) patients with long-term levodopa therapy. Monitoring of plasma levodopa concentrations and clinical effects has been reported to benefit the management of these complications. However, to our knowledge, there is no data available in Taiwan concerning the correlation between the plasma levodopa levels and motor fluctuations. In this study, we developed the laboratory methodology for plasma levodopa determination by using the aluminum extraction procedure and HPLC-ED. Serial blood samples and motor scores were obtained from 7 PD patients, and the correlation between plasma levodopa levels and motor responses were studied individually. In three patients with wearing-off phenomenon, plasma levodopa concentrations are compatible with the clinical 'on' and 'off' states. In the other four patients with complex fluctuating responses, their levodopa dosages were adjusted by the results of monitoring. Better motor responses were achieved by optimization of the levodopa pharmacokinetics in these patients. Our preliminary data suggest that simultaneous monitoring of plasma levodopa concentrations and clinical effects might be helpful to improve the therapeutic strategy in some of the parkinsonian patients with fluctuating responses to levodopa. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463738 | ISSN: | 0257-5655 | SDG/關鍵字: | benserazide plus levodopa; levodopa; adult; aged; article; clinical article; controlled study; drug blood level; drug determination; drug monitoring; female; high performance liquid chromatography; human; male; motor activity; on off phenomenon; Parkinson disease; Adult; Aged; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease |
顯示於: | 醫學系 |
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