Risk of Hypoglycemia and Concomitant Use of Repaglinide and Clopidogrel: A Population-Based Nested Case-Control Study
Journal
Clinical Pharmacology and Therapeutics
Journal Volume
106
Journal Issue
6
Pages
1346
Date Issued
2019
Author(s)
Abstract
© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics This nested case-control study evaluated the potential interaction between repaglinide and clopidogrel. Cases were defined by inpatient admissions or emergency department visits due to hypoglycemia. Concomitant use of repaglinide and clopidogrel within 3 days before the hypoglycemic event was the exposure of interest. For each case, up to four controls were randomly selected and matched by age, sex, type of glinide used (repaglinide or nateglinide), and time since cohort entry to the index date. Hypoglycemic risk was estimated by conditional logistic regressions. Concomitant use of repaglinide and clopidogrel was associated with an increased risk of hypoglycemia compared with repaglinide alone (adjusted odds ratio: 2.42; 95% confidence interval: 1.75−3.35). No significant associations were found with the two negative control object drug concomitants: nateglinide and clopidogrel and repaglinide and aspirin (without clopidogrel use). Our study suggests drug interaction between clopidogrel and repaglinide is clinically relevant and could increase the risk for hypoglycemia.
SDGs
Other Subjects
acetylsalicylic acid; clopidogrel; gemfibrozil; metformin; nateglinide; repaglinide; sulfonylurea; acetylsalicylic acid; antidiabetic agent; antithrombocytic agent; carbamic acid derivative; clopidogrel; nateglinide; piperidine derivative; repaglinide; aged; Article; case control study; cohort analysis; combination drug therapy; comorbidity; controlled study; diabetes mellitus; dyslipidemia; female; human; hypoglycemia; major clinical study; male; monotherapy; population based case control study; priority journal; drug interaction; hypoglycemia; middle aged; Aged; Aspirin; Carbamates; Case-Control Studies; Clopidogrel; Drug Interactions; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Piperidines; Platelet Aggregation Inhibitors
Publisher
WILEY
Type
journal article