https://scholars.lib.ntu.edu.tw/handle/123456789/463886
標題: | Non-invasive Photodynamic Therapy in Brain Cancer by Use of Tb3+-Doped LaF3 Nanoparticles in Combination with Photosensitizer Through X-ray Irradiation: A Proof-of-Concept Study | 作者: | Chen, M.-H. Jenh, Y.-J. Wu, S.-K. Chen, Y.-S. Hanagata, N. FENG-HUEI LIN |
關鍵字: | Brain cancer; LaF3:Tb; Non-invasive; Photodynamic therapy; X-ray | 公開日期: | 2017 | 卷: | 12 | 期: | 1 | 來源出版物: | Nanoscale Research Letters | 摘要: | The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a specific light wavelength produces the predominant cytotoxic agent, to destroy tumor cells. However, delivering an efficient light source to the brain tumor site is still a challenge. The light source should be delivered by placing external optical fibers into the brain at the time of surgical debulking of the tumor. Consequently, there exists the need for a minimally invasive treatment for brain cancer PDT. In this study, we investigated an attractive non-invasive option on glioma cell line by using Tb3+-doped LaF3 scintillating nanoparticles (LaF3:Tb) in combination with photosensitizer, meso-tetra(4-carboxyphenyl)porphyrin (MTCP), followed by activation with soft X-ray (80?kVp). Scintillating LaF3:Tb nanoparticles, with sizes of approximately 25?nm, were fabricated. The particles have a good dispersibility in aqueous solution and possess high biocompatibility. However, significant cytotoxicity was observed in the glioma cells while the LaF3:Tb nanoparticles with MTCP were exposed under X-ray irradiation. The study has demonstrated a proof of concept as a non-invasive way to treat brain cancer in the future. ? 2017, The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463886 | DOI: | 10.1186/s11671-017-1840-3 | SDG/關鍵字: | Biocompatibility; Cell culture; Cytotoxicity; Diseases; Doping (additives); Irradiation; Lanthanum compounds; Light sources; Nanoparticles; Optical fiber fabrication; Optical fibers; Photodynamic therapy; Photosensitizers; Scintillation; Solutions; Terbium compounds; Tumors; Brain cancer; Glioma cell lines; LaF3 nanoparticles; Minimally invasive treatments; Non-invasive; Photodynamic therapy (PDT); Tetra (4 carboxyphenyl)porphyrin; X ray irradiation; X rays |
顯示於: | 醫學工程學研究所 |
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