https://scholars.lib.ntu.edu.tw/handle/123456789/463913
標題: | Studies of magnetic alginate-based electrospun matrices crosslinked with different methods for potential hyperthermia treatment | 作者: | Chen, Y.-H. Cheng, C.-H. Chang, W.-J. Lin, Y.-C. Lin, F.-H. Lin, J.-C. Lin, Feng-Huei |
關鍵字: | Alginate; Electrospinning; Hyperthermia; Magnetic electrospun mats; Magnetic nanoparticles | 公開日期: | 2016 | 卷: | 62 | 起(迄)頁: | 338-349 | 來源出版物: | Materials Science and Engineering C | 摘要: | The magnetic electrospun mats were lately established as an innovative biomaterial for hyperthermic cancer treatment. Unlike those surface-modified magnetic nanoparticles that may not firmly adhere onto the tumor for long-term duration, the magnetic mats with nanofibrous structure can promote cell adhesion and kill the tumor directly within an alternating magnetic field. However, most magnetic electrospun mats were fabricated using non-biodegradable polymers and organic solvents, causing the problems of removal after therapy and the suspected biotoxicity associated with residual solvent. Alginate (SA) was utilized in this investigation as the main material for electrospinning because of being biodegradable and water-soluble. The alginate-based electrospun mats were then treated by an ionic or a covalent crosslinking method, and then followed by chelation with Fe2 +/Fe3 + for chemical coprecipitation of Fe3O4 magnetic nanoparticles. Significant less cytotoxicity was noted on both liquid extracts from the ionic-crosslinked (Fe3O4-SA/PEO) and covalent-crosslinked (Fe3O4-SA/PVA) magnetic electrospun mats as well as the surface of Fe3O4-SA/PVA. In vitro hyperthermia assay indicated that the covalent-crosslinked magnetic alginate-based mats reduced tumor cell viability greater than Fe3O4 nanoparticles. Such magnetic electrospun mats are of potential for hyperthermia treatment by endoscopic/surgical delivery as well as serving as a supplementary debridement treatment after surgical tumor removal. ? 2016 Elsevier B.V. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463913 | DOI: | 10.1016/j.msec.2016.01.070 | SDG/關鍵字: | Alginate; Biodegradable polymers; Cell adhesion; Coprecipitation; Crosslinking; Electrospinning; Hyperthermia therapy; Magnetism; Nanofibers; Nanoparticles; Organic polymers; Spinning (fibers); Tumors; Alternating magnetic field; Chemical co-precipitation; Covalent crosslinking; Electrospun mats; Hyperthermia; Hyperthermia treatments; Magnetic nano-particles; Non-biodegradable polymers; Nanomagnetics; alginic acid; glucuronic acid; hexuronic acid; magnetite nanoparticle; animal; chemistry; materials testing; mouse; NIH 3T3 cell line; thermotherapy; Alginates; Animals; Glucuronic Acid; Hexuronic Acids; Hyperthermia, Induced; Magnetite Nanoparticles; Materials Testing; Mice; NIH 3T3 Cells |
顯示於: | 醫學工程學研究所 |
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