Tailoring highly branched poly(β-amino ester)s: A synthetic platform for epidermal gene therapy
Journal
Chemical Communications
Journal Volume
51
Journal Issue
40
Pages
8473-8476
Date Issued
2015
Author(s)
Huang, J.-Y.
Gao, Y.
Cutlar, L.
O'Keeffe-Ahern, J.
Zhao, T.
Lin, F.-H.
Zhou, D.
McMahon, S.
Greiser, U.
Wang, W.
Wang, W.
Abstract
Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.
SDGs
Type
journal article