https://scholars.lib.ntu.edu.tw/handle/123456789/463923
標題: | Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia | 作者: | Liao, S.-H. Liu, C.-H. Bastakoti, B.P. Suzuki, N. Chang, Y. Yamauchi, Y. Lin, F.-H. KEVIN CHIA-WEN WU FENG-HUEI LIN |
公開日期: | 2015 | 卷: | 10 | 起(迄)頁: | 3315-3328 | 來源出版物: | International Journal of Nanomedicine | 摘要: | Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fuid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic feld, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems. ? 2015 Liao et al. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463923 | DOI: | 10.2147/IJN.S68719 | SDG/關鍵字: | alginic acid; galactosamine; iron oxide; nanomaterial; superparamagnetic iron oxide nanoparticle; alginic acid; ferric ion; ferric oxide; glucuronic acid; hexuronic acid; nanoparticle; aqueous solution; Article; biocompatibility; cell transport; controlled study; hepatocellular carcinoma cell line; human; human cell; hyperthermia; in vitro study; infrared spectroscopy; magnetic field; particle size; precipitation; scanning electron microscopy; surface property; thermogravimetry; X ray diffraction; blood clotting; chemistry; drug delivery system; drug effects; fever; Hep-G2 cell line; procedures; temperature; Alginates; Blood Coagulation; Chemical Precipitation; Drug Delivery Systems; Ferric Compounds; Fever; Galactosamine; Glucuronic Acid; Hep G2 Cells; Hexuronic Acids; Humans; Magnetic Fields; Microscopy, Electron, Scanning; Nanoparticles; Spectroscopy, Fourier Transform Infrared; Temperature; Thermogravimetry; X-Ray Diffraction |
顯示於: | 醫學工程學研究所 |
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