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  1. NTU Scholars
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  3. 醫學工程學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/463954
Title: Hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) with enhanced drug loading and pH-responsive release properties for intracellular drug delivery
Authors: Yang, Y.-H.
Liu, C.-H.
Liang, Y.-H.
Lin, F.-H.
KEVIN CHIA-WEN WU 
FENG-HUEI LIN 
Issue Date: 2013
Journal Volume: 1
Journal Issue: 19
Start page/Pages: 2447-2450
Source: Journal of Materials Chemistry B
Abstract: 
Biocompatible and biodegradable hydroxyapatite nanoparticles with a hollow core and mesoporous shell structure (denoted as hmHANPs) are synthesized by an opposite ion core/shell strategy and applied to pH-responsive intracellular drug delivery systems (DDS). The synthesized hmHANPs have several advantages over solid hydroxyapatite nanoparticles (HANPs), where the hollow and mesoporous structure enhances drug-loading capacity, and the thin hydroxyapatite shell structure reduces burst release of drug and provides pH-responsive release. Doxorubicin (DOX), a therapeutic anticancer drug, was loaded in hmHANPs and HANPs for intracellular drug delivery systems (DDS). Compared to HANPs having a low drug-loading efficacy (17.9%), hmHANPs exhibited an excellent drug-loading efficacy (93.7%). In addition, the release amount of DOX from hmHANPs was 2.5-fold the amount from HANPs. Compared with free DOX, the anticancer efficacy of DOX-loaded hmHANPs was greatly enhanced, as evidenced by the results of MTT assays and confocal laser scanning microscopy using breast cancer cells (BT-20). The synthesized hmHANPs show great potential as drug nanovehicles with high biocompatibility, enhanced drug loading, and pH-responsive features for future intracellular DDS. ? The Royal Society of Chemistry 2013.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/463954
DOI: 10.1039/c3tb20365d
SDG/Keyword: Breast cancer cells; Confocal laser scanning microscopy; Hydroxyapatite nanoparticles; Intracellular drug delivery; Mesoporous hydroxyapatites; Mesoporous shell; Mesoporous structures; Release property; Biocompatibility; Drug delivery; Hydroxyapatite; Mesoporous materials; Nanoparticles; Synthesis (chemical); Loading
[SDGs]SDG3
Appears in Collections:醫學工程學研究所

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