https://scholars.lib.ntu.edu.tw/handle/123456789/463954
Title: | Hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) with enhanced drug loading and pH-responsive release properties for intracellular drug delivery | Authors: | Yang, Y.-H. Liu, C.-H. Liang, Y.-H. Lin, F.-H. KEVIN CHIA-WEN WU FENG-HUEI LIN |
Issue Date: | 2013 | Journal Volume: | 1 | Journal Issue: | 19 | Start page/Pages: | 2447-2450 | Source: | Journal of Materials Chemistry B | Abstract: | Biocompatible and biodegradable hydroxyapatite nanoparticles with a hollow core and mesoporous shell structure (denoted as hmHANPs) are synthesized by an opposite ion core/shell strategy and applied to pH-responsive intracellular drug delivery systems (DDS). The synthesized hmHANPs have several advantages over solid hydroxyapatite nanoparticles (HANPs), where the hollow and mesoporous structure enhances drug-loading capacity, and the thin hydroxyapatite shell structure reduces burst release of drug and provides pH-responsive release. Doxorubicin (DOX), a therapeutic anticancer drug, was loaded in hmHANPs and HANPs for intracellular drug delivery systems (DDS). Compared to HANPs having a low drug-loading efficacy (17.9%), hmHANPs exhibited an excellent drug-loading efficacy (93.7%). In addition, the release amount of DOX from hmHANPs was 2.5-fold the amount from HANPs. Compared with free DOX, the anticancer efficacy of DOX-loaded hmHANPs was greatly enhanced, as evidenced by the results of MTT assays and confocal laser scanning microscopy using breast cancer cells (BT-20). The synthesized hmHANPs show great potential as drug nanovehicles with high biocompatibility, enhanced drug loading, and pH-responsive features for future intracellular DDS. ? The Royal Society of Chemistry 2013. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463954 | DOI: | 10.1039/c3tb20365d | SDG/Keyword: | Breast cancer cells; Confocal laser scanning microscopy; Hydroxyapatite nanoparticles; Intracellular drug delivery; Mesoporous hydroxyapatites; Mesoporous shell; Mesoporous structures; Release property; Biocompatibility; Drug delivery; Hydroxyapatite; Mesoporous materials; Nanoparticles; Synthesis (chemical); Loading [SDGs]SDG3 |
Appears in Collections: | 醫學工程學研究所 |
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