https://scholars.lib.ntu.edu.tw/handle/123456789/463986
標題: | Silica-modified Fe-doped calcium sulfide nanoparticles for in vitro and in vivo cancer hyperthermia | 作者: | Wu, S.Y.-H. Yang, K.-C. Tseng, C.-L. Chen, J.-C. Lin, F.-H. Lin, Feng-Huei |
關鍵字: | Calcium sulfide; Hyperthermia; Iron-doped magnetic nanoparticles; Nanomedicine; Silica; Surface modification; Targeted tumor | 公開日期: | 2011 | 卷: | 13 | 期: | 3 | 起(迄)頁: | 1139-1149 | 來源出版物: | Journal of Nanoparticle Research | 摘要: | In this study, sulfide-based magnetic Fe-doped CaS nanoparticles modified with a silica layer were investigated for cancer hyperthermia. A polyvinyl pyrrolidone polymer was used as the coupling agent. The developed nanoparticles contained 11.6 wt% iron concentration, and their X-ray diffraction pattern was similar to those of CaS and Fe-CaS nanoparticles. The average particle size was approximately 47.5 nm and homogeneously dispersed in aqueous solutions. The major absorption bands of silica were observed from the FTIR spectrum. The magnetic properties and heating efficiency were also examined. The specific absorption ratio of nanoparticles at a concentration of 10 mg/mL at 37°C in an ethanol carrier fluid was 37.92 W/g, and the nanoparticles would raise the temperature to over 45°C within 15 min. A cytotoxicity analysis revealed that the nanoparticles had good biocompatibility, which indicated that the nanoparticles did not affect cell viability. The therapeutic effects of the nanoparticles were investigated using in vitro and animal studies. Cells seeded with nanoparticles and treated under an AC magnetic field revealed a percentage of cytotoxicity (60%) that was significantly higher from that in other groups. In the animal study, during a hyperthermia period of 15 days, tumor-bearing Balb/c mice that were subcutaneously injected with nanoparticles and exposed to an AC magnetic field manifested a reduction in tumor volume. The newly developed silica-modified Fe-CaS nanoparticles can thus be considered a promising and attractive hyperthermia thermoseed. ? 2010 Springer Science+Business Media B.V. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463986 | DOI: | 10.1007/s11051-010-0106-0 | SDG/關鍵字: | Calcium sulfide; Hyperthermia; Magnetic nanoparticles; Nanomedicines; Surface modification; Targeted tumor; Absorption; Absorption spectroscopy; Animals; Biocompatibility; Coupling agents; Diffraction; Diseases; Ethanol; Magnetic fields; Magnetic properties; Medical nanotechnology; Nanoparticles; Silica; Tumors; X ray diffraction; Nanomagnetics; alcohol; iron; iron calcium sulfide nanoparticle; magnetic nanoparticle; nanoparticle; silicon dioxide; unclassified drug; absorption; animal experiment; animal model; aqueous solution; article; biocompatibility; cancer hyperthermia; cell viability; concentration (parameters); controlled study; cytotoxicity; heating; hyperthermia; in vitro study; in vivo study; infrared spectroscopy; magnetic field; mouse; nonhuman; particle size; priority journal; temperature; tumor volume; X ray diffraction |
顯示於: | 醫學工程學研究所 |
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