https://scholars.lib.ntu.edu.tw/handle/123456789/463999
標題: | Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation | 作者: | Yang, K.C. Qi, Z. Lin, F.H. Wu, C.C. Sumi, S. Lin, Feng-Huei |
關鍵字: | Chitosan hydrogel; Encapsulation; Immunoisolation; Type 1 diabetes; Xenotransplantation | 公開日期: | 2010 | 卷: | 27 | 起(迄)頁: | 179-181 | 來源出版物: | IFMBE Proceedings | 摘要: | Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation. ? Springer-Verlag 2010. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463999 | DOI: | 10.1007/978-3-642-12020-6-44 | SDG/關鍵字: | Anthropometry; Biomedical engineering; Chitosan; Encapsulation; Mammals; Blood glucose level; Body weight; Chitosan hydrogel; Diabetic mice; Immuno-isolation; Islet transplantation; Type 1 diabetes; Xenotransplantation; Hydrogels |
顯示於: | 醫學工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。