Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Engineering / 工學院
  3. Biomedical Engineering / 醫學工程學系
  4. Biomechanical response of intact, degenerated and repaired intervertebral discs under impact loading – Ex-vivo and In-Silico investigation
 
  • Details

Biomechanical response of intact, degenerated and repaired intervertebral discs under impact loading – Ex-vivo and In-Silico investigation

Journal
Journal of Biomechanics
Journal Volume
70
Pages
26-32
Date Issued
2018
Author(s)
Nikkhoo, M.
Wang, J.-L.
Parnianpour, M.
El-Rich, M.
Khalaf, K.
JAW-LIN WANG  
DOI
10.1016/j.jbiomech.2018.01.026
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/464252
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041579036&doi=10.1016%2fj.jbiomech.2018.01.026&partnerID=40&md5=2ec6d0a68ef52112d2bc0a004307eeba
Abstract
Understanding the effect of impact loading on the mechanical response of the intervertebral disc (IVD) is valuable for investigating injury mechanisms and devising effective therapeutic modalities. This study used 24 porcine thoracic motion segments to characterize the mechanical response of intact (N = 8), degenerated (Trypsin-denatured, N = 8), and repaired (Genepin-treated, N = 8) IVDs subject to impact loading. A meta-model analysis of poroelastic finite element simulations was used in combination with ex-vivo creep and impact tests to extract the material properties. Forward analyses using updated specimen-specific FE models were performed to evaluate the effect of impact duration. The maximum axial stress in the IVDs, Von-Mises stress in the endplates, and intradiscal pore pressure (IDP) were calculated, under a 400 N preload, subject to a sequence of impact loads for 10 impact durations (10–100 ms). The results were in good agreement with both creep and impact experiments (error < 10%). A significant difference was found in the maximum axial stress between the intact and degenerated disc groups. The IDP was also significantly lower in the degenerated disc group. The Von Mises stress in the adjacent endplates significantly increased with degeneration. It is concluded that the disc time-dependent response significantly changes with disc degeneration. Cross-linker Genipin has the potential to recover the hydraulic permeability and can potentially change the time dependent response, particularly in the IDP. This is the first study, to our best knowledge, which explores the effect of impact loading on the healthy, degenerated and repaired IVD using both creep and impact validation tests. ? 2018 Elsevier Ltd
Subjects
Degeneration; Ex-vivo experiments; Finite element analysis; Genipin repair; Impact loading; Intervertebral disc
SDGs

[SDGs]SDG3

Other Subjects
Creep; Dental prostheses; Implants (surgical); Degeneration; Ex-vivo; Genipin; Impact loadings; Intervertebral discs; Finite element method; genipin; iridoid; animal tissue; Article; axial stress; biomechanics; computer model; controlled study; ex vivo study; finite element analysis; human; hydraulic permeability; impact loading; intervertebral disk; intervertebral disk degeneration; intradiscal pore pressure; juvenile animal; musculoskeletal system parameters; nonhuman; pig; priority journal; simulation; validation process; Von Mises stress; animal; biological model; biomechanics; computer simulation; intervertebral disk; mechanical stress; pathophysiology; physiology; pressure; weight bearing; Animals; Biomechanical Phenomena; Computer Simulation; Finite Element Analysis; Intervertebral Disc; Intervertebral Disc Degeneration; Iridoids; Models, Biological; Pressure; Stress, Mechanical; Swine; Weight-Bearing
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science