Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells
Journal
Blood
Journal Volume
104
Journal Issue
10
Pages
3233-3242
Date Issued
2004
Author(s)
Huang, Chiu-Chen
Jeng, Chung-Jiuan
Su, Ho-Ting
Chiang, Evelyn
Liu, Meng-Ru
Wu, C. H. Herbert
Chang, Chung-Nan
Lin, Rong-Hwa
Abstract
Increasing evidence has shown that death signaling in T cells is regulated in a complicated way. Molecules other than death receptors can also trigger T-cell death. Here, we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti-PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T cells. In contrast to classic cell death, PSGL-1-mediated T-cell death is caspase independent. It involves translocation of apoptosis-inducing factor from mitochondria to nucleus and mitochondrial cytochrome c release. Ultrastructurally, both peripheral condensation of chromatin and apoptotic body were observed in PSGL-1-mediated T-cell death. Collectively, this study demonstrates a novel role for PSGL-1 in controlling activated T-cell death and, thus, advances our understanding of immune regulation.
SDGs
Type
journal article