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  4. Fluorospectral study of the rat brain and glioma in vivo
 
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Fluorospectral study of the rat brain and glioma in vivo

Journal
Lasers in Surgery and Medicine
Journal Volume
13
Journal Issue
3
Pages
321-331
Date Issued
1993
Author(s)
JUI-CHANG TSAI  
Kao M.?C.
Hsiao Y.?Y.
DOI
10.1002/lsm.1900130309
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027221768&doi=10.1002%2flsm.1900130309&partnerID=40&md5=f01be5fa58ec4859ceccfdfff9651d0e
https://scholars.lib.ntu.edu.tw/handle/123456789/465299
Abstract
An animal model of cerebral glioma was utilized by implanting C6 glioma cells into the brains of adult Wistar rats. Once tumors developed to 7–12 mm in diameter, we conducted continuous fluorimetry monitoring of glioma up to 24 hours using a fibre?optic system connected to an intensified multichannel photodetector after an intravenous injection of hematoporphyrin derivative (HPD) into the rats. The intensity of the fluorescence in normal brain reached a plateau 6 hours after intravenous injection of HPD while that in glioma reached a plateau 80 minutes after injection. These fluorescence intensities of glioma, brain adjacent to tumor (BAT), and surrounding normal brain were measured in vivo 24 hours after intravenous administration of 5 mg/kg of HPD. The ratio of fluorescence intensities between glioma and brain was 6.1 while the ratio between BAT and brain was 3.9. There were no obvious differences in shapes between the spectra of the natural fluorescence (autofluorescence) of rat glioma and brain but the intensity of autofluorescence was much weaker in glioma. There are many problems in spectroscopic studies of biological tissues in vivo. It cannot be overemphasized that very strict criteria must be applied in order to get accurate data. Fluorescence from HPD administration may be used to discriminate tumor tissue from surrounding normal brain tissue during operation if the measuring conditions could be kept constant. It is important to understand the photospectral properties of glioma and brain tissue in order to get the most benefits in clinical application of light?induced fluorescence or photoradiation therapy. ? 1993 Wiley?Liss, Inc. Copyright ? 1993 Wiley?Liss, Inc., A Wiley Company
SDGs

[SDGs]SDG3

Other Subjects
animal tissue; article; autofluorescence; brain tissue; cancer diagnosis; cancer localization; diagnostic imaging; glioma; image analysis; light; nonhuman; phototherapy; rat; spectrofluorometry; Absorption; Animal; Brain; Brain Neoplasms; Chromatography, High Pressure Liquid; Feasibility Studies; Fluorescence; Glioma; Hematoporphyrin Derivative; Kidney; Kinetics; Liver; Male; Rats; Rats, Wistar; Signal Processing, Computer-Assisted; Spectrometry, Fluorescence; Spleen; Support, Non-U.S. Gov't; Tumor Cells, Cultured
Type
journal article

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