In vitro release of hydrocortisone by glycine-immobilized EVAL membrane
Journal
Biomedical Engineering - Applications, Basis and Communications
Journal Volume
17
Journal Issue
2
Pages
86-90
Date Issued
2005
Author(s)
Abstract
A pH-sensitive membrane for colon-specific drug delivery was prepared by glycine-immobilization on poly (ethylene-co-vinyl alcohol) (Gly-EVAL) that can enhance the permeability of hydrocortisone at pH 7.4 and resist drug permeation at pH 2.0 or in gastric juice. As the results of drug releasing profile, it is proposed that the electrical repulsion occurring between adjacent carboxylate ions at pH 7.4 on Gly-EVAL causes the higher permeation rate of hydrocortisone. Consequently, the hydrocortisone coated by Gly-EVAL can escape from degradation in acid environment and release significantly in neutral or weak basic pH values, which is ideally suitable for local treatment of ulcerative colitis.
SDGs
Type
journal article
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