https://scholars.lib.ntu.edu.tw/handle/123456789/465714
標題: | Near-Infrared Fluorescent Dye-Decorated Nanocages to Form Grenade-like Nanoparticles with Dual Control Release for Photothermal Theranostics and Chemotherapy | 作者: | Lin C.-Y. MING-JIUM SHIEH |
公開日期: | 2018 | 出版社: | American Chemical Society | 卷: | 29 | 期: | 4 | 起(迄)頁: | 1384-1398 | 來源出版物: | Bioconjugate Chemistry | 摘要: | Recently, nanoparticles (NPs) have been widely investigated for delivery of anticancer drugs. Here, a dual control drug-release modality was developed that uses naturally occurring protein apoferritin loaded with doxorubicin (DOX) and ADS-780 near-infrared (NIR) fluorescent dye-decorated NPs (ADNIR NPs). ADNIR NPs act as a grenade to detonate the targeted tumor site following laser irradiation (photothermal therapy, PTT) and explode into cluster warheads (apoferritin-loaded DOX nanocages, AF-DOX NCs) that further destroy the tumor cells (chemotherapy). Light was shown to disrupt the grenade-like structure of NPs to release AF-DOX NCs as well as DOX from NCs in low-pH intercellular environments. In vitro and in vivo studies showed that the structure of AF-DOX NCs was disassembled to release DOX, which then killed the cancer cells in organelles with acidic environments. In vivo studies showed that the ADNIR NP-decorated with NIR dye facilitated tracking of the accumulated NPs at the tumor site using an IVIS imaging system. Overall, targeted ADNIR NPs with dual-release mechanisms were developed for use in photothermal theranostic and chemotherapy. This modality has high potential for application in cancer treatment and clinical translation for drug delivery and imaging. ? 2018 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045544864&doi=10.1021%2facs.bioconjchem.8b00088&partnerID=40&md5=93f24a58629879464706c3d60e3047f7 https://scholars.lib.ntu.edu.tw/handle/123456789/465714 |
ISSN: | 1043-1802 | DOI: | 10.1021/acs.bioconjchem.8b00088 | SDG/關鍵字: | Chemotherapy; Controlled drug delivery; Diseases; Fluorescence; Infrared devices; Projectiles; Targeted drug delivery; Tumors; Anticancer drug; Apoferritin; Control release; Doxorubicin; Dual control; Nanocages; Near-infrared fluorescent dyes; Photo-thermal; Theranostics; Tumor site; Nanoparticles; ads 780; apoferritin; doxorubicin; fluorescent dye; nanocage; nanoparticle; unclassified drug; antineoplastic antibiotic; apoferritin; doxorubicin; fluorescent dye; nanoparticle; animal cell; animal experiment; animal model; animal tissue; Article; cancer chemotherapy; cancer inhibition; cell killing; cell organelle; colorectal cancer; confocal microscopy; controlled drug release; controlled study; drug blood level; drug cytotoxicity; drug delivery system; drug distribution; drug efficacy; drug half life; drug structure; female; HT-29 cell line; in vitro study; in vivo study; mouse; near infrared spectroscopy; nonhuman; pH; photothermal therapy; temperature; theranostic nanomedicine; tumor cell; volume of distribution; administration and dosage; animal; Bagg albino mouse; colon tumor; delayed release formulation; diagnostic imaging; drug therapy; fluorescence imaging; human; infrared radiation; nude mouse; pathology; phototherapy; procedures; theranostic nanomedicine; thermotherapy; ultrastructure; Animals; Antibiotics, Antineoplastic; Apoferritins; Colonic Neoplasms; Delayed-Action Preparations; Doxorubicin; Drug Delivery Systems; Female; Fluorescent Dyes; HT29 Cells; Humans; Hyperthermia, Induced; Infrared Rays; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Optical Imaging; Phototherapy; Theranostic Nanomedicine |
顯示於: | 醫學工程學研究所 |
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