Photothermal, Targeting, Theranostic Near-Infrared Nanoagent with SN38 against Colorectal Cancer for Chemothermal Therapy
Journal
Molecular Pharmaceutics
Journal Volume
14
Journal Issue
8
Pages
2766-2780
Date Issued
2017
Author(s)
Abstract
Cancer research regarding near-infrared (NIR) agents for chemothermal therapy (CTT) has shown that agents with specific functions are able to inhibit tumor growth. The aim of current study was to optimize CTT efficacy for treatment of colorectal cancer (CRC) by exploring strategies which can localize high temperature within tumors and maximize chemotherapeutic drug uptake. We designed a new and simple multifunctional NIR nanoagent composed of the NIR cyanine dye, polyethylene glycol, and a cyclic arginine-glycine-aspartic acid peptide and loaded with the anti-CRC chemotherapeutic agent, 7-ethyl-10-hydroxy-camptothecin (SN38). Each component of this nanoagent exhibited its specific functions that help boost CTT efficacy. The results showed that this nanoagent greatly strengthens the theranostic effect of SN38 and CTT against CRC due to its NIR imaging ability, photothermal, enhanced permeability and retention (EPR) effect, reticuloendothelial system avoidance, and angiogenic blood vessel-targeting properties. This NIR nanoagent will help facilitate development of new strategies for treating CRC. ? 2017 American Chemical Society.
Subjects
chemothermal therapy; colorectal cancer; cRGD; IR780; SN38
SDGs
Other Subjects
arginylglycylaspartic acid; cyanine dye; firtecan; macrogol; 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; antineoplastic agent; camptothecin; indole derivative; irinotecan; nanoparticle; animal experiment; animal model; antineoplastic activity; Article; cancer inhibition; cancer therapy; colorectal cancer; drug absorption; drug release; drug synthesis; drug uptake; female; human; human cell; human cell culture; in vitro study; in vivo study; mouse; near infrared chemothermal therapy; nonhuman; photothermal therapy; priority journal; theranostic nanomedicine; analogs and derivatives; chemistry; colorectal tumor; phototherapy; procedures; theranostic nanomedicine; tumor cell line; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Humans; Indoles; Nanoparticles; Phototherapy; Theranostic Nanomedicine
Publisher
American Chemical Society
Type
journal article