https://scholars.lib.ntu.edu.tw/handle/123456789/465736
標題: | Combining the single-walled carbon nanotubes with low voltage electrical stimulation to improve accumulation of nanomedicines in tumor for effective cancer therapy | 作者: | Lee P.-C. Peng C.-L. MING-JIUM SHIEH |
關鍵字: | Cancer therapy; Electroporation; Nanomedicine; Single-walled carbon nanotube; Tumor | 公開日期: | 2016 | 出版社: | Elsevier B.V. | 卷: | 225 | 起(迄)頁: | 140-151 | 來源出版物: | Journal of Controlled Release | 摘要: | Effective delivery of biomolecules or functional nanoparticles into target sites has always been the primary objective for cancer therapy. We demonstrated that by combining single-walled carbon nanotubes (SWNTs) with low-voltage (LV) electrical stimulation, biomolecule delivery can be effectively enhanced through reversible electroporation (EP). Clear pore formation in the cell membrane is observed due to LV (50 V) pulse electrical stimulation amplified by SWNTs. The cell morphology remains intact and high cell viability is retained. This modality of SWNT + LV pulses can effectively transfer both small molecules and macromolecules into cells through reversible EP. The results of animal studies also suggest that treatment with LV pulses alone cannot increase vascular permeability in tumors unless after the injection of SWNTs. The nanoparticles can cross the permeable vasculature, which enhances their accumulation in the tumor tissue. Therefore, in cancer treatment, both SWNT + LV pulse treatment followed by the injection of LIPO-DOX? and SWNT/DOX + LV pulse treatment can increase tumor inhibition and delay tumor growth. This novel treatment modality applied in a human cancer xenograft model can provide a safe and effective therapy using various nanomedicines in cancer treatment. ? 2016 Elsevier B.V. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961296568&doi=10.1016%2fj.jconrel.2016.01.038&partnerID=40&md5=c7e663264e63e5b911f0f9821fed3866 https://scholars.lib.ntu.edu.tw/handle/123456789/465736 |
ISSN: | 0168-3659 | DOI: | 10.1016/j.jconrel.2016.01.038 | SDG/關鍵字: | Biomolecules; Carbon nanotubes; Cells; Cytology; Diseases; Medical nanotechnology; Nanoparticles; Nanotubes; Oncology; Tumors; Yarn; Biomolecule deliveries; Cancer therapy; Electrical stimulations; Electroporation; Functional nanoparticles; Single-walled carbon nanotube (SWNTs); Treatment modality; Vascular permeability; Single-walled carbon nanotubes (SWCN); doxorubicin; poloxamer; single walled nanotube; antineoplastic antibiotic; carbon nanotube; doxorubicin; macrogol derivative; animal experiment; animal model; apoptosis; Article; blood vessel permeability; cancer inhibition; cancer therapy; cell permeabilization; cell structure; cell viability; channel gating; controlled study; drug delivery system; electroporation; electrostimulation; female; HT 29 cell line; human; human cell; in vivo study; low voltage electrical stimulation; macromolecule; mouse; nanomedicine; neoplasm; nonhuman; priority journal; scanning electron microscopy; tumor growth; tumor volume; tumor xenograft; vascularization; analogs and derivatives; animal; Bagg albino mouse; drug effects; HT-29 cell line; metabolism; nanomedicine; Neoplasms; nude mouse; pathology; Animals; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Electric Stimulation; Female; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Nanomedicine; Nanotubes, Carbon; Neoplasms; Polyethylene Glycols; Tumor Burden |
顯示於: | 醫學工程學研究所 |
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