Gold nanoshells with micellar core for the delivery of hydrophobic chemotherapeutic and cancer photothermal therapy
Journal
Advanced Materials - TechConnect Briefs 2016
Journal Volume
3
Pages
161-164
Date Issued
2016
Author(s)
Lee S.-Y.
Abstract
In the present study, we established a multifunctional gold nanoshell (GNS) that utilizing positively charged PDMA-b-PCL micelles as a template. By growing the gold layer on the surface of micelles, this newly synthesized GNS with micellar core enable the delivery of hydrophobic chemotherapeutics. The synthesized SN-38@pGNS had a spherical morphology and a narrow size distribution. With the exposure to NIR laser irradiation, SN-38@pGNS exhibited an excellent photothermal conversion efficiency. Moreover, the combination of chemotherapy and photothermal therapy resulted in a significant anticancer effect in the in vitro study. These results suggested the gold nanoshells with micellar core can serve as not only a photothermal mediator but also a delivery system for hydrophobic drugs. Therefore, the synthesized gold nanoshells with micellar core can be applied as a potential multifunctional therapeutics for cancer therapy in the future.
Subjects
Chemotherapy; Gold nanoshell; Micelles; Photothermal therapy; SN-38
SDGs
Other Subjects
Chemotherapy; Diseases; Gold; Hydrophobicity; Micelles; Nanostructured materials; Nanostructures; Anticancer effects; Cancer photothermal therapies; Gold nanoshells; Narrow size distributions; NIR laser irradiation; Photothermal conversion efficiencies; Photothermal therapy; Spherical morphologies; Nanoshells
Publisher
TechConnect
Type
conference paper