https://scholars.lib.ntu.edu.tw/handle/123456789/465758
標題: | Multi-functional micelles for the combination of chemotherapy and radiotherapy in hepatocellular carcinoma | 作者: | Shih Y.-H. Peng C.-L. Luo T.-Y. MING-JIUM SHIEH |
關鍵字: | Doxorubicin; Micelles; PCNA; Rhenium-188 | 公開日期: | 2013 | 卷: | 1 | 起(迄)頁: | 385-387 | 來源出版物: | 2013 NSTI Nanotechnology Conference and Expo | 摘要: | In this study, multi-functional micelles loaded with doxorubicin (Dox) and labeled with the radionuclide rhenium-188 (188Re) were developed to provide the combination therapy for liver cancer. BNL/Luc heptoma mice were randomly allocated to four groups. Including PBS control (n=4), 88Re- perrhenate (n=4), Dox micelles (n=5) and 188Re Dox-micelles (n=5). The biodsitribution and therapeutic efficacy were mesured. Bio-luminescence imaging of BNL/Luc heptoma showed the smallest tumor size in 188Re-Dox micelles group (p<0.05). Moreover, 188Re-Dox micelles group had more than thirty days survival, which was significantly different with control (p<0.005). Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) shows that 188Re-Dox micelles inhibited the proliferation of BNL/Luc cell comparing with control (p<0.001). We suggested the 188Re Dox-micelles could apply for the combined therapies of hepatoma. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84881100055&partnerID=40&md5=957e5e13d436a534bf060ab0302519e1 https://scholars.lib.ntu.edu.tw/handle/123456789/465758 |
SDG/關鍵字: | Combination therapy; Doxorubicin; Hepatocellular carcinoma; Immunohistochemical staining; PCNA; Proliferating cell nuclear antigens; Rhenium-188; Therapeutic efficacy; Cell proliferation; Chemotherapy; Exhibitions; Films; Nanocomposite films; Nanotechnology; Rhenium; Micelles |
顯示於: | 醫學工程學研究所 |
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