https://scholars.lib.ntu.edu.tw/handle/123456789/465767
Title: | Enhanced cell electro-permeabilisation combined with phototherapy to target-killing cancer cells by using multi functional carbon nanotubes | Authors: | Lee P.-C. MING-JIUM SHIEH |
Keywords: | Carbon nanotubes; Electro-permeabilisation; Hyperthermia; Photodynamic therapy | Issue Date: | 2011 | Journal Volume: | 3 | Start page/Pages: | 379-381 | Source: | 2011 NSTI Nanotechnology Conference and Expo | Abstract: | Carbon nanotubes (CNTs) have been proposed and actively explored as multifunctional innovative carriers for drug delivery. This study presents a new modality for cell electro-permeabilisation based on the use of CNTs and external static electric fields to achieve highly drug delivery efficiency. Besides, CNTs are unique materials that absorb infrared (IR) radiation in the special spectral window where body tissues are most transparent. Absorbed IR promotes molecular oscillation leading to efficient heating of the surrounding environment. By using these characteristics of CNTs, we conjugated photosensitizers on chemically functionalized single-wall carbon nanotubes (f-SWNTs) to combine photodynamic therapy and hyperthermia for killing cancer cells specifically and effectively. Thus, CNT complex drug delivery is promising for improving the efficacy of drug delivery and treatment to decrease side effects for future cancer therapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-81455143850&partnerID=40&md5=af2c5bea441bb8cbfb3d12c189839ca8 https://scholars.lib.ntu.edu.tw/handle/123456789/465767 |
SDG/Keyword: | Body tissues; Cancer cells; Cancer therapy; Electro-permeabilisation; Functionalized; Hyperthermia; Molecular oscillations; Multi-functional; New modality; Phototherapy; Side effect; Static electric fields; Surrounding environment; Carbon; Carbon nanotubes; Cells; Diseases; Drug delivery; Electric fields; Fluidics; Hyperthermia therapy; Medical nanotechnology; Nanotechnology; Photodynamic therapy; Photosensitizers; Tissue; Single-walled carbon nanotubes (SWCN) |
Appears in Collections: | 醫學工程學研究所 |
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