AS1411 aptamer-conjugated polymeric micelle for targetable cancer therapy
Journal
2010 NSTI Nanotechnology Conference and Expo
Journal Volume
3
Pages
330-333
Date Issued
2010
Author(s)
Abstract
Targetable drug delivery system is a promising tool for cancer treatments. Herein we report a novel strategy of using G-quadruplex AS1411 aptamer-conjugated polyethylene-polylactide formed polymeric micelles (apt-PEG-PLA-PM) as a drug carrier to target cancer cells for chemotherapy. G-quadruplex AS1411 aptamer is known to target to nucleolin over-expressed in cancer cells. In this study, the effect of AS1411 aptamer-conjugated polymeric micelle for drug delivery via nucleolin-mediated internalization was investigated. Our results showed that the apt-PEG-PLA-PM exhibited higher cytotoxicity in MCF-7 breast cancer cells than in M10 normal epithelium cells. It is suggested that the apt-PEG-PLA-PM was mainly internalized into cells via the specific interaction of AS1411 aptamer with nucleolin on the cell surface and this nucleolin-targetable polymeric micelle can be a potential drug carrier for cancer therapy.
Subjects
AS1411; Cancer therapy; Polymeric micelle
SDGs
Other Subjects
Aptamers; AS1411; Cancer cells; Cancer therapy; Cancer treatment; Cell surfaces; Drug carrier; Drug delivery system; Epithelium cells; G-quadruplexes; MCF-7 breast cancer cells; Novel strategies; Nucleolin; Peg-pla; Poly lactide; Polymeric micelle; Potential drug; Specific interaction; Cell membranes; Chemotherapy; Drug delivery; Drug interactions; Medical nanotechnology; Oncology; Sensors; Micelles
Type
conference paper