Reduced skin photosensitivity with meta -tetra(hydroxyphenyl)chlorin-loaded micelles based on a poly(2-ethyl-2-oxazoline)- b -poly(d, l -lactide) diblock copolymer in vivo
Journal
Molecular Pharmaceutics
Journal Volume
7
Journal Issue
4
Pages
1244-1253
Date Issued
2010
Author(s)
Abstract
Photodynamic therapy (PDT) is a light-induced chemical reaction that produces localized tissue damage for the treatment of cancers and other nonmalignant conditions. The activation of photosensitizers in a target tissue is accomplished with a specific light source in the presence of molecular oxygen. In the clinic, patients treated with PDT should be kept away from direct sunlight or strong indoor lighting to avoid skin phototoxicity. In this study, a photosensitizer encapsulated within a micelle was developed to overcome this problem. The pH-sensitive micelles were successfully incorporated with meta-tetra(hydroxyphenyl)chlorin (m-THPC), and the cytotoxicity and antitumor effects were investigated in vitro and in vivo. Our results demonstrated that PDT with m-THPC-loaded micelles had no significant adverse effects on the body weight of mice in vivo. Furthermore, after an extended delivery time, m-THPC-loaded micelles and free m-THPC had similar antitumor effects, but the m-THPC-loaded micelles had less skin phototoxicity. Thus, this strategy could be used as a potential nanocarrier for PDT-mediated cancer therapy. ? 2010 American Chemical Society.
Subjects
cancer therapy; micelle; Photodynamic therapy; photosensitivity; photosensitizer
SDGs
Other Subjects
meta tetra(hydroxyphenyl)chlorin; photosensitizing agent; poly(2 ethyl 2 oxazoline) b poly(dextro, levo lactide); unclassified drug; animal experiment; animal model; article; body weight; cytotoxicity; drug mechanism; drug synthesis; in vivo study; male; micelle; nonhuman; photodynamic therapy; photosensitivity; priority journal; skin sensitivity; Animals; Cell Line, Tumor; Female; HT29 Cells; Humans; Mesoporphyrins; Mice; Mice, Inbred BALB C; Micelles; Oxazoles; Photochemotherapy; Photosensitizing Agents; Polyesters; Polymers; Skin
Type
journal article