https://scholars.lib.ntu.edu.tw/handle/123456789/465827
標題: | A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier | 作者: | Lin, Feng-Huei Lee Y.H. Jian C.H. Wong J.-M. MING-JIUM SHIEH Wang C.-Y. |
關鍵字: | 5-Fluorouracil; Ion exchange; Montmorillonite | 公開日期: | 2002 | 卷: | 23 | 期: | 9 | 起(迄)頁: | 1981-1987 | 來源出版物: | Biomaterials | 摘要: | Since its introduction over 40 years ago, 5-fluorouracil (5-FU) has remained the only effective chemotherapy option available for the treatment of colorectal cancer (CRC). However, this cytotoxic anticancer drug often causes severe side effects because it does not act selectively on the tumor. It has been reported that the 5-FU showed considerable toxicity when administered by intravenous injections or via alimentary tract. Although, many materials have been developed for carrying 5-FU, there has been no clinically acceptable carrier for 5-FU till now. Montmorillonite, one of the clay minerals, consists of hydrated aluminum silicates with fine grains and large spaces between the layers. Isomorphous substitution of cations is common. In the study, we attempt to intercalate 5-FU into interlayers of montmorillonite through ion exchange. Montmorillonite was purified from crude clays of bentonite in Tai-dong, Taiwan by filtration and sedimentation. Solutions of 5-FU with different concentrations were prepared by dissolving various amounts of 5-FU into 10ml NaOH solution. Purified montmorillonite powder was soaked in 5-FU solution for a period of time with different pH values and temperatures. In this study, we try to intercalate 5-FU into interlayers of montmorillonite to find out optimum conditions, such as soaking time, temperature, pH value, initial 5-FU concentration, etc., to prepare composites of 5-FU and montmorillonite (5-FU/mont). UV, SDT, FTIR, XRD are used to characterize the 5-FU/mont composite. From the results, 5-FU was successfully intercalated into the interlayer of montmorillonite both by free surface absorption and OH replacement. The optimum condition for 5-FU/mont preparations is 1.185wt% of 5-FU as initial concentration under a pH value of 11.6 at a temperature of 80°C and a soaking time of 2h. The total amount of 5-FU in montmorillonite is about 87.5mg for each gram of montmorillonite, which can be proved by thermal gravimetric analysis. The composite of 5-FU/mont is expected to achieve in situ release for colorectal cancer therapy in future applications. ? 2002 Elsevier Science Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036201728&doi=10.1016%2fS0142-9612%2801%2900325-8&partnerID=40&md5=31ee904bd153460b215cafa45aa1292f https://scholars.lib.ntu.edu.tw/handle/123456789/465827 |
ISSN: | 0142-9612 | DOI: | 10.1016/S0142-9612(01)00325-8 | SDG/關鍵字: | Absorption; Aluminum compounds; Clay minerals; Fourier transform infrared spectroscopy; Intercalation compounds; Ion exchange; pH effects; Positive ions; Powders; Sedimentation; Solutions; Substitution reactions; Thermogravimetric analysis; Tumors; X ray diffraction analysis; Free surface absorption; Chemotherapy; fluorouracil; intercalating agent; montmorillonite; sodium hydroxide; absorption; article; drug synthesis; filtration; infrared spectroscopy; ion exchange; pH; priority journal; purification; sedimentation; temperature; thermogravimetry; ultraviolet radiation; X ray diffraction; Aluminum Silicates; Antimetabolites, Antineoplastic; Bentonite; Cations; Chromatography, Ion Exchange; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Carriers; Fluorouracil; Humans; Hydrogen-Ion Concentration; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Temperature; Time Factors; Ultraviolet Rays; X-Ray Diffraction |
顯示於: | 醫學工程學研究所 |
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