https://scholars.lib.ntu.edu.tw/handle/123456789/465916
標題: | Association between the risk of lung cancer and influenza: A population-based nested case-control study | 作者: | Weng C.-F. Chen L.-J. Lin C.-W. Chen H.-M. Lee H.H.-C. THAI-YEN LING FEI-YUAN HSIAO |
公開日期: | 2019 | 卷: | 88 | 起(迄)頁: | 8-13 | 來源出版物: | International Journal of Infectious Diseases | 摘要: | Background: Previous animal studies have shown that certain respiratory oncoviruses can lead to tumorigenesis, especially influenza virus. However, no clinical studies other than animal studies have been conducted to test this hypothesis. Objective: To investigate the association between influenza and the risk of lung cancer using the Taiwan Cancer Registry Database (TCRD) and Taiwan's National Health Insurance Research Database (NHIRD). Methods: We identified a study cohort consisting of patients aged 40 years or above who were enrolled in the NHIRD between 1 January 2012 and 31 December 2014. Among them, we identified patients with lung cancer (cases) and their matched controls (matched by age, sex, and disease risk score (DRS) at a ratio of 1:10). Multivariate conditional logistic regression models were used to evaluate the association between exposure to influenza (timing and cumulative number) and risk of lung cancer. Results: We identified 32,063 cases and 320,627 matched controls. Influenza was associated with a 1.09-fold increased risk of lung cancer (aOR 1.09, 95% CI 1.04–1.14, p < 0.0001). The risk of lung cancer increased slightly with cumulative exposure to influenza (1–2 exposures: aOR 1.05, 95% CI 1.00–1.11; 3-4 exposures: aOR 1.12, 95% CI 1.00–1.25; 5+ exposures: aOR 1.25, 95% CI 1.13–1.39). Conclusion: Exposure to influenza was associated with an increased risk of lung cancer and the risk increased with cumulative exposure to influenza. However, the lack of valid information on smoking could lead to confounding, and future studies collecting patients’ smoking histories are warranted to validate the association between influenza and lung cancer. ? 2019 The Authors |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/465916 | ISSN: | 12019712 | DOI: | 10.1016/j.ijid.2019.07.030 | SDG/關鍵字: | adult; age; aged; Article; cancer risk; case control study; cohort analysis; controlled study; disease association; disease risk assessment; female; human; influenza; lung cancer; major clinical study; male; risk assessment; smoking; Taiwan; adverse event; complication; factual database; influenza; lung tumor; middle aged; risk; statistical model; Adult; Case-Control Studies; Cohort Studies; Databases, Factual; Female; Humans; Influenza, Human; Logistic Models; Lung Neoplasms; Male; Middle Aged; Risk; Smoking; Taiwan |
顯示於: | 藥理學科所 |
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