The relation of amino-terminal propeptide of type III procollagen and severity of coronary artery disease in patients without myocardial infarction or hibernation
Journal
Clinical Biochemistry
Journal Volume
39
Journal Issue
9
Pages
861-866
Date Issued
2006
Author(s)
Abstract
Objectives: The association of cardiac fibrosis and coronary artery disease (CAD) in patients without infarction or hibernation is unclear. We investigated the relationship between serum concentrations of procollagen propeptides and severity of CAD in such patients. Design and methods: Forty-six patients (32 men; mean age 64 years) with chest pain were enrolled. All patients received stress thallium-201 single photon emission computed tomography (SPECT) and analysis of the serum levels of the amino-terminal propeptide of type I and III procollagen (PINP and PIIINP). Results: In patients with thallium-201 perfusion defects, the number of diseased vessels was associated significantly with PIIINP (p = 0.024) rather than PINP (p = 0.613). Follow-up serum PINP and PIIINP levels after coronary intervention (mean 84 days) revealed no significant decrease. Conclusions: Serum PIIINP level is significantly associated with the severity of CAD in patients without myocardial infarction or hibernation. ? 2006.
SDGs
Other Subjects
dipyridamole; procollagen type 3 aminopropeptide; thallium 201; adult; aged; apparatus; article; blood sampling; clinical article; computed tomographic angiography; coronary artery disease; diagnostic imaging; disease severity; echocardiography; female; follow up; heart infarction; heart muscle fibrosis; hibernation; human; hypertension; image analysis; male; percutaneous coronary intervention; priority journal; protein blood level; single photon emission computer tomography; stress; thorax pain; Aged; Biological Markers; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Echocardiography; Female; Heart Catheterization; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Peptide Fragments; Procollagen; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
43.pdf
Size
155.59 KB
Format
Adobe PDF
Checksum
(MD5):a967ede24d6d91c97fd14289088389d0