https://scholars.lib.ntu.edu.tw/handle/123456789/467121
Title: | Biomaterial aided differentiation and maturation of induced pluripotent stem cells | Authors: | Velmurugan B.K. Bharathi Priya L. Poornima P. LI-JEN LEE Baskaran R. |
Keywords: | biomaterials; induced pluripotent stem cells; regenerative medicine; scaffolds | Issue Date: | 2019 | Publisher: | Wiley-Liss Inc. | Journal Volume: | 234 | Journal Issue: | 6 | Start page/Pages: | 8443-8454 | Source: | Journal of Cellular Physiology | Abstract: | Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self-renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine. ? 2018 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058841854&doi=10.1002%2fjcp.27769&partnerID=40&md5=223d5b7fd2401d6de60d5f2dff6db81a https://scholars.lib.ntu.edu.tw/handle/123456789/467121 |
ISSN: | 0021-9541 | DOI: | 10.1002/jcp.27769 | SDG/Keyword: | biomaterial; molecular scaffold; biomaterial; bone; cardiac muscle cell; cartilage; cell differentiation; cell maturation; cell regeneration; cell reprogramming technique; cells by body anatomy; human; induced pluripotent stem cell; liver cell; nerve cell; nonhuman; nuclear reprogramming; priority journal; regenerative medicine; Review; tissue engineering; topography; cell differentiation; cell lineage; cell proliferation; cell self-renewal; cytology; drug effect; induced pluripotent stem cell; Biocompatible Materials; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Self Renewal; Cellular Reprogramming; Humans; Induced Pluripotent Stem Cells; Regenerative Medicine |
Appears in Collections: | 解剖學暨細胞生物學科所 |
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