Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 解剖學暨細胞生物學科所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/467167
Title: Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway
Authors: Chou C.-H.
Huang M.-J.
CHI-HAU CHEN 
MING-KWANG SHYU 
Huang J.
JI-SHIANG HUNG 
CHIUN-SHENG HUANG 
MIN-CHUAN HUANG 
Issue Date: 2015
Publisher: Impact Journals LLC
Journal Volume: 6
Journal Issue: 8
Start page/Pages: 6123-6135
Source: Oncotarget
Abstract: 
Aberrant glycosylation is frequently observed in cancers. Core 1 β1,3- galactosyltransferase (C1GALT1) is an exclusive enzyme in humans that catalyzes the biosynthesis of core 1 O-glycan structure, Gal-GalNAc-O-Ser/Thr, whose expression is commonly up-regulated during tumorigenesis. Little is known about the function of C1GALT1 in breast cancer. This study aims to determine the correlation between C1GALT1 expression and breast cancer clinicopathological features and roles of C1GALT1 in breast cancer malignant phenotypes. Public databases and our data showed that C1GALT1 mRNA and C1GALT1 protein are frequently up-regulated in breast cancer; and increased C1GALT1 expression correlates with higher histological grade and advanced tumor stage. Overexpression of C1GALT1 enhanced breast cancer cell growth, migration, and invasion in vitro as well as tumor growth in vivo. Conversely, C1GALT1 knockdown suppressed these malignant phenotypes. Furthermore, C1GALT1 modulates O-glycan structures on Mucin (MUC) 1 and promotes MUC1-C/β-catenin signaling in breast cancer cells. These findings suggest that C1GALT1 enhances breast cancer malignant progression through promoting MUC1- C/β-catenin signaling pathway. Unveiling the function of C1GALT1 in breast cancer opens new insights to the roles of C1GALT1 and O-glycosylation in tumorigenesis and renders the potential of C1GALT1 as a target of novel therapeutic agent development.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925662960&doi=10.18632%2foncotarget.3045&partnerID=40&md5=428fdaf0fd52eb9dbfa812379735d489
https://scholars.lib.ntu.edu.tw/handle/123456789/467167
ISSN: 1949-2553
DOI: 10.18632/oncotarget.3045
SDG/Keyword: beta catenin; core 1 beta1,3 galactosyltransferase; galactosyltransferase; glycoprotein; messenger RNA; mucin 1C; small interfering RNA; unclassified drug; beta catenin; C1GALT1 protein, human; galactosyltransferase; MUC1 protein, human; mucin 1; animal experiment; animal model; animal tissue; Article; breast cancer; breast cancer cell line; breast carcinoma; C1GALT1 gene; cancer grading; cancer growth; cancer inhibition; cancer staging; cell migration; controlled study; correlation analysis; female; gene silencing; human; human tissue; in vitro study; in vivo study; mouse; nonhuman; protein expression; protein function; protein glycosylation; signal transduction; tumor invasion; tumor promotion; upregulation; animal; breast tumor; enzymology; genetic transfection; genetics; metabolism; pathology; SCID mouse; signal transduction; tumor cell line; xenograft; Animals; beta Catenin; Breast Neoplasms; Cell Line, Tumor; Female; Galactosyltransferases; Heterografts; Humans; Mice; Mice, SCID; Mucin-1; Signal Transduction; Transfection; Up-Regulation
[SDGs]SDG3
Appears in Collections:解剖學暨細胞生物學科所

Show full item record

SCOPUSTM   
Citations

45
checked on Mar 27, 2023

WEB OF SCIENCETM
Citations

44
checked on Mar 19, 2023

Page view(s) 20

32
checked on Mar 27, 2023

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback