Hydrogels based on schiff base linkages for biomedical applications
Journal
Molecules
Journal Volume
24
Journal Issue
16
Date Issued
2019
Author(s)
Abstract
Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and functions after damages. Moreover, pH-sensitivity of the Schiff base offers the hydrogels response to biologically relevant stimuli. Different types of Schiff base can provide the hydrogels with tunable mechanical properties and chemical stabilities. In this review, we summarized the design and preparation of hydrogels based on various types of Schiff base linkages, as well as the biomedical applications of hydrogels in drug delivery, tissue regeneration, wound healing, tissue adhesives, bioprinting, and biosensors. © 2019 by the authors.
Subjects
Click chemistry; Dynamic covalent bond; Hydrogel; Schiff base; Self-healing; Tissue engineering
Other Subjects
Schiff base; tissue adhesive; animal; chemistry; click chemistry; drug delivery system; drug effect; human; hydrogel; procedures; wound healing; Animals; Click Chemistry; Drug Delivery Systems; Humans; Hydrogels; Schiff Bases; Tissue Adhesives; Wound Healing
Type
review