International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome
Journal
Journal of the Peripheral Nervous System
Journal Volume
22
Journal Issue
2
Pages
68-76
Date Issued
2017
Author(s)
Jacobs B.C.
van den Berg B.
Verboon C.
Chavada G.
Cornblath D.R.
Gorson K.C.
Harbo T.
Hartung H.-P.
Hughes R.A.C.
Kusunoki S.
van Doorn P.A.
Gilhuis H.J.
Goldstein J.M.
Goyal N.
Granit V.
Grapperon A.
Gutiérrez Gutiérrez, G.
Gutmann L.
Hadden R.D.M.
Holbech J.V.
Holt J.K.L.
Willison H.J.
Homedes Pedret C.
Htut M.
Jellema K.
Jericó Pascual I.
Kaida K.
Karafiath S.
Katzberg H.D.
Kiers L.
Kieseier B.C.
Kimpinski K.
the IGOS Consortium, Jacobs B.C.
Kleyweg R.P.
Kokubun N.
Kolb N.A.
Kuitwaard K.
Kuwabara S.
Kwan J.Y.
Ladha S.S.
Landschoff Lassen L.
Lawson V.
Ledingham D.
Hughes R.A.C.
Léon Cejas L.
Luciano C.A.
Lucy S.T.
Lunn M.P.T.
Magot A.
Manji H.
Marchesoni C.
Marfia G.A.M.
Márquez Infante C.
Martinez Hernandez E.
Cornblath D.R.
Mataluni G.
Mattiazi M.
McDermott C.J.
Meekins G.D.
Miller J.
Monges M.S.
Montero M.C.J.
Morís de la Tassa G.
Nascimbene C.
Neumann C.
Gorson K.C.
Nowak R.J.
Orizaola Balaguer P.
Osei-Bonsu M.
Pan E.B.L.
Pardo Fernandez J.
Pasnoor M.
Pulley M.T.
Rajabally Y.A.
Rinaldi S.
Ritter C.
Hartung H.P.
Roberts R.C.
Rojas-Marcos I.
Rudnicki S.A.
Sachs G.M.
Samijn J.P.A.
Santoro L.
Saperstein D.S.
Savransky A.
Schneider H.
Schenone A.
Kusunoki S.
Sedano Tous M.J.
Sekiguchi Y.
Sheikh K.A.
Silvestri N.J.
Sindrup S.H.
Sommer C.L.
Stein B.
Stino A.M.
Spyropoulos A.
Srinivasan J.
van Doorn P.A.
Suzuki H.
Taylor S.W.
Tankisi H.
Tigner D.
Twydell P.T.
Valzania F.
van Damme P.
van der Kooi A.J.
van Dijk G.W.
van der Ree T.
Willison H.J.
van Koningsveld R.
Varrato J.D.
Vermeij F.H.
Verschuuren J.J.G.M.
Visser L.H.
Vytopil M.V.
Waheed W.
Wilken M.
Wilkerson C.
Wirtz P.W.
van Woerkom M.
Yamagishi Y.
Yiu E.M.
Zhou L.
Zivkovic S.
van den Berg B.
Verboon C.
Roodbol J.
Jacobs B.C.
Reisin R.C.
Reddel S.W.
Islam Z.
Islam B.
Mohammad Q.D.
van den Bergh P.
Feasby T.E.
Wang Y.Z.
Harbo T.
Péréon Y.
Hartung H.P.
Lehmann H.C.
Dardiotis E.
Nobile-Orazio E.
Shahrizaila N.
Bateman K.
Illa I.
Querol L.A.
Chavada G.
Davidson A.
Addington J.M.
Ajroud-Driss S.
Andersen H.
Antonini G.
Attarian S.
Badrising U.
Barroso F.A.
Benedetti L.
Beronio A.
Bianco M.
Binda D.
Briani C.
Bürmann J.
Bella I.R.
Bertorini T.E.
Bhavaraju-Sanka R.
Brannagan T.H.
Busby M.
Butterworth S.
Campagnolo M.
Casasnovas C.
Cavaletti G.
Chao C.S.
Chen S.
Chetty S.
Claeys K.G.
Cohen J.A.
Conti M.E.
Cosgrove J.S.
Dalakas M.C.
Dimachkie M.M.
Dillmann U.
Domínguez González, C.
Doppler K.
Dornonville de la Cour C.
Echaniz-Laguna A.
Eftimov F.
Faber C.G.
Fazio R.
Fokke C.
Fujioka T.
Fulgenzi E.A.
Galassi G.
Garcia T.
Garnero M.
Garssen M.P.J.
Gijsbers C.J.
Gilchrist J.M.
Abstract
Guillain-Barr? syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1–3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS. ? 2017 Peripheral Nerve Society
Subjects
biomarkers; diagnosis; Guillain-Barr? syndrome; outcome; prognosis; treatment
SDGs
Other Subjects
DNA; adult; Article; blood sampling; cerebrospinal fluid; child; clinical feature; clinical protocol; cohort analysis; demography; disease course; disease severity; electrophysiology; environmental factor; follow up; Guillain Barre syndrome; human; infection; major clinical study; observational study; outcome assessment; priority journal; prospective study; disease exacerbation; female; Guillain Barre syndrome; international cooperation; male; metabolism; outcome assessment; pathophysiology; Cohort Studies; Disease Progression; Female; Guillain-Barre Syndrome; Humans; International Cooperation; Male; Observational Studies as Topic; Outcome Assessment (Health Care)
Publisher
Blackwell Publishing Inc.
Type
journal article