|Title:||Brain imaging signatures of the relationship between epidermal nerve fibers and heat pain perception||Authors:||MING-TSUNG TSENG
|Issue Date:||2015||Publisher:||Academic Press Inc.||Journal Volume:||122||Start page/Pages:||288-297||Source:||NeuroImage||Abstract:||
Although the small-diameter primary afferent fibers in the skin promptly respond to nociceptive stimuli and convey sensory inputs to the central nervous system, the neural signatures that underpin the relationship between cutaneous afferent fibers and pain perception remain elusive. We combined skin biopsy at the lateral aspect of the distal leg, which is used to quantify cutaneous afferent fibers, with fMRI, which is used to assess brain responses and functional connectivity, to investigate the relationship between cutaneous sensory nerves and the corresponding pain perception in the brain after applying heat pain stimulation to the dorsum of the right foot in healthy subjects. During painful stimulation, the degree of cutaneous innervation, as measured by epidermal nerve fiber density, was correlated with individual blood oxygen level-dependent (BOLD) signals of the posterior insular cortex and of the thalamus, periaqueductal gray, and rostral ventromedial medulla. Pain perception was associated with the activation of the anterior insular cortex and with the functional connectivity from the anterior insular cortex to the primary somatosensory cortex during painful stimulation. Most importantly, both epidermal nerve fiber density and activity in the posterior insular cortex showed a positive correlation with the strength of coupling under pain between the anterior insular cortex and the primary somatosensory cortex. Thus, our findings support the notion that the neural circuitry subserving pain perception interacts with the cerebral correlates of peripheral nociceptive fibers, which implicates an indirect role for skin nerves in human pain perception. ? 2015 Elsevier Inc.
|ISSN:||1053-8119||DOI:||10.1016/j.neuroimage.2015.08.021||SDG/Keyword:||adult; aged; Article; BOLD signal; brain analysis; central nervous system; clinical article; controlled study; female; functional magnetic resonance imaging; heat; human; image analysis; insula; male; nerve fiber; nociception; oxygen blood level; periaqueductal gray matter; posterior insula; primary somatosensory cortex; priority journal; rostral ventromedial medulla; sensory nerve; sensory stimulation; skin biopsy; skin nerve; somatosensory cortex; thalamus; thermal stimulation; brain; brain mapping; cytology; epidermis; heat; innervation; middle aged; nociception; nuclear magnetic resonance imaging; pain receptor; physiology; stimulation; Adult; Aged; Brain; Brain Mapping; Epidermis; Female; Hot Temperature; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nociception; Nociceptors; Physical Stimulation
|Appears in Collections:||解剖學暨細胞生物學科所|
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