https://scholars.lib.ntu.edu.tw/handle/123456789/467874
標題: | Plasma β-Amyloids and Tau Proteins in Patients with Vascular Cognitive Impairment | 作者: | SUNG-CHUN TANG KAI-CHIEN YANG CHIH-HAO CHEN Yang S.-Y. MING-JANG CHIU CHAU-CHUNG WU JIANN-SHING JENG |
公開日期: | 1-十二月-2018 | 卷: | 20 | 期: | 4 | 起(迄)頁: | 498 | 來源出版物: | NeuroMolecular Medicine | 摘要: | Increases in plasma of β-amyloids (Aβ) and tau proteins have been noted in patients with Alzheimer’s dementia (AD). Our study investigated the associations of plasma Aβ and tau proteins with dementia in stroke patients. This cross-sectional study recruited 24 controls (mean age: 67.4 ± 7.5 years, 33.3% male), 27 stroke patients without dementia (mean age: 70.7 ± 6.9 years, 60.7% male), 34 stroke patients with dementia (mean age: 78.3 ± 5.3 years, 45.5% male, Clinical Dementia Ranking (CDR): 1.46 ± 0.63), and 21?AD patients (mean age: 77.1 ± 9.1 years, 42.9% male, CDR: 1.43 ± 0.60) from a medical center. Dementia was defined as a CDR scale score of ? 1. The plasma levels of Aβ-40, Aβ-42, and tau were analyzed using immunomagnetic reduction. One-way analysis of variance was used to compare the differences in measured protein levels between the groups. The results indicated that plasma levels of tau and Aβ-42, but not Aβ-40, in stroke patients were significantly higher than in the controls. After adjustment for age, sex, diabetes mellitus, hypertension, and hyperlipidemia, only plasma level of Aβ-42 remained significantly higher in stroke patients with dementia than in those without dementia (OR 1.85, 1.25–2.75, p = 0.002). In summary, our results suggest that plasma Aβ-42 is a potential biomarker for dementia in stroke patients. ? 2018, Springer Science+Business Media, LLC, part of Springer Nature. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/467874 | ISSN: | 1535-1084 | DOI: | 10.1007/s12017-018-8513-y | SDG/關鍵字: | amyloid beta protein; amyloid beta protein[1-40]; amyloid beta protein[1-42]; biological marker; tau protein; amyloid beta protein; biological marker; tau protein; age distribution; aged; Article; case control study; cerebrovascular accident; Clinical Dementia Rating; controlled study; cross-sectional study; diabetes mellitus; disease association; female; human; hyperlipidemia; hypertension; immunomagnetic separation; major clinical study; male; multiinfarct dementia; pathophysiology; priority journal; prospective study; protein blood level; sex difference; stroke patient; blood; dyslipidemia; multiinfarct dementia; psychology; severity of illness index; very elderly; Aged; Aged, 80 and over; Amyloid beta-Peptides; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Dementia, Vascular; Diabetes Mellitus; Dyslipidemias; Female; Humans; Hypertension; Male; Prospective Studies; Severity of Illness Index; Stroke; tau Proteins |
顯示於: | 醫學系 |
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