https://scholars.lib.ntu.edu.tw/handle/123456789/468540
標題: | Anti-inflammatory strategies for homocysteine-related cardiovascular disease | 作者: | Lin C.-P. Chen Y.-H. Leu H.-B. Lin S.-J. YUH-LIEN CHEN Huang S.-L. Chen J.-W. |
公開日期: | 2009 | 卷: | 14 | 期: | 10 | 起(迄)頁: | 3836-3845 | 來源出版物: | Frontiers in Bioscience | 摘要: | Homocysteine may induce vascular damage for atherosclerosis. Vitamin/folate supplementation has been proposed to reduce the cardiovascular disease risk. Nevertheless, there has no randomized clinical trial clearly proven the efficacy of reducing the homocysteine as a means of lowering the incidence of cardiovascular disease. Homocysteine induces oxidative stress leading to endothelial dysfunction. In addition, homocysteine-induced oxidative stress favors lipid peroxidation and induces production of inflammatory factors, thus accelerating atherosclerosis. In this paper, we reviewed the available evidence concerning the association between homocysteine and cardiovascular disease, with the objective of discussing the pertinence of screening, treatment, and prevention of hyperhomocysteinemia-related cardiovascular disease. Our previous findings also indicate the significant role of mononuclear cells activation in homocysteine-induced endothelial dysfunction; treatment with statins attenuated homocysteine-induced endothelial adhesiveness, indicating the novel endothelial protection effects of statins in the presence of homocysteine. Since inflammation and oxidative stress is critical to homocysteine-induced vascular damage, the inhibition of endothelial dysfunction and mononuclear cell activation by anti-inflammatory and/or antioxidative drugs/agents may serve as a potential therapeutic strategy for hyperhomocysteinemia-related cardiovascular disease. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-63849097233&doi=10.2735%2f3492&partnerID=40&md5=96ac45bede5e0fe1764a20be75451d56 https://scholars.lib.ntu.edu.tw/handle/123456789/468540 |
ISSN: | 1093-9946 | DOI: | 10.2735/3492 | SDG/關鍵字: | antiinflammatory agent; antioxidant; homocysteine; blood; cardiovascular disease; human; physiology; review; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Diseases; Homocysteine; Humans |
顯示於: | 解剖學暨細胞生物學科所 |
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