Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules
Journal
Cardiovascular and Hematological Disorders - Drug Targets
Journal Volume
6
Journal Issue
4
Pages
279-304
Date Issued
2006
Author(s)
Abstract
Atherosclerosis is a chronic inflammatory process. The adhesion of leukocytes to the vascular endothelium, mediated by endothelial cell adhesion molecules including vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin, is the pivotal early event in atherogenesis. Inflammatory cytokines could activate redox-sensitive transcription factors and induce endothelial expression of adhesion molecules, which could be inhibited to various degrees by different antioxidants suggesting the potential role of endogenous reactive oxygen species (ROS) in atherogenesis. Many clinical drugs that against cardiovascular diseases have exhibited antioxidant effects; these drugs simultaneously inhibit endothelial adhesion molecule expression, such as aspirin, probucol, HMG-CoA reductase inhibitors, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, peroxisome proliferator-activated receptor α and γ ligands, calcium channel blockers, β-adrenergic blockers, etc. In addition, we have previously demonstrated that Ginkgo biloba extract, a Chinese herb with antioxidant activity, could significantly suppress inflammatory cytokine-stimulated endothelial adhesiveness to human monocytic cells by attenuating intracellular ROS formation, redox-senstive transcription factor activation, and VCAM-1 as well as ICAM-1 expression in human aortic endothelial cells. The similar anti-atherosclerosis effects have been also shown in other Chinese herbs or dietary supplements with antioxidant activity such as magnolol and salvianolic acid B either in vitro or in vivo. Thus, oxidative stress is critical to endothelial adhesiveness in atherogenesis. The inhibition of endothelial adhesion molecule expression by drugs/agents with antioxidant activity may serve as a potential therapeutic strategy for clinical atherosclerosis. ? 2006 Bentham Science Publishers Ltd.
SDGs
Other Subjects
acetylsalicylic acid; angiotensin receptor antagonist; antioxidant; atorvastatin; beta adrenergic receptor blocking agent; calcium channel blocking agent; cerivastatin; compactin; cytokine; diclofenac; dipeptidyl carboxypeptidase inhibitor; endothelial leukocyte adhesion molecule 1; fluindostatin; Ginkgo biloba extract; herbaceous agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; indometacin; intercellular adhesion molecule 1; ketoprofen; magnolol; peroxisome proliferator activated receptor alpha agonist; peroxisome proliferator activated receptor gamma agonist; probucol; reactive oxygen metabolite; rosuvastatin; salvianolic acid B; simvastatin; transcription factor; unindexed drug; vascular cell adhesion molecule 1; antiinflammatory activity; antioxidant activity; aorta; article; atherogenesis; atherosclerosis; cardiovascular disease; Chinese herb; diet supplementation; endothelium cell; enzyme inhibition; human; in vitro study; in vivo study; leukocyte adherence; monocyte; nonhuman; oxidative stress; protein expression; vascular endothelium
Publisher
Bentham Science Publishers B.V.
Type
journal article