https://scholars.lib.ntu.edu.tw/handle/123456789/468708
標題: | Pericardial fat is associated with ventricular tachyarrhythmia andmortality in patients with systolic heart failure | 作者: | CHO-KAI WU Tsai H.-Y. MAO-YUAN SU Wu Y.-F. HWANG, JUEY-JEN WEN-YIH TSENG JIUNN-LEE LIN LIAN-YU LIN |
公開日期: | 2015 | 出版社: | Elsevier Ireland Ltd | 卷: | 241 | 期: | 2 | 起(迄)頁: | 607-614 | 來源出版物: | Atherosclerosis | 摘要: | Objective: Pericardial fat (PF) has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity which might be associated with the presence of arrhythmia or even worse outcomes. The aims of this study was to characterize the relationship between PF and the prognosis in patients with systolic heart failure (HF). Methods: This is a retrospective cohort study of a cardiac magnetic resonance imaging (CMRI) database from 2004 to 2011. Fifty patients with systolic HF underwent CMRI examinations were included. We also enrolled twenty patients with HF as the control group. The cine imaging was analyzed to derive total PF volumes, left ventricular volumes and mass and left ventricular ejection fraction by using a previously validated technique. The outcomes, including ventricular tachycardia (VT), ventricular fibrillation (VF) and total mortality were obtained by reviewing medical records. Results: After a median follow-up of 694 days, patients with VT/VF had significant larger indexed PF volumes than those without [36.3 (32.8-43.1) ml/m2 vs. 24.1 (20.2-27.6) ml/m2, p=0.001]. The mortality group also had significant larger indexed PF volumes (PF/body surface area) than those without [31.3 (22.8-38.4) ml/m2 vs. 23.9 (19.8-27.3) ml/m2, p=0.010]. Indexed PF volumes were associated with the development of VT/VF (Hazard ratio, 7.510; 95% C.I, 0.901-62.582, p=0.062) and mortality (Hazard ratio, 3.998; 95% C.I, 1.077-14.845, p=0.038) by Cox's regression analyses. Conclusion: PF is associated with the development of VT/VF and long-term overall mortality in patients with systolic HF. ? 2015 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935029203&doi=10.1016%2fj.atherosclerosis.2015.05.025&partnerID=40&md5=308e9274f304682a78cac40a44e27256 https://scholars.lib.ntu.edu.tw/handle/123456789/468708 |
ISSN: | 0021-9150 | DOI: | 10.1016/j.atherosclerosis.2015.05.025 | SDG/關鍵字: | adipose tissue; adult; Article; body surface; cardiovascular magnetic resonance; cardiovascular mortality; cardiovascular parameters; controlled study; disease association; disease course; female; follow up; heart left ventricle ejection fraction; heart left ventricle mass; heart left ventricle volume; heart ventricle fibrillation; heart ventricle tachycardia; human; major clinical study; male; medical record review; outcome assessment; pericardial fat; pericardial fat volume; priority journal; prognosis; retrospective study; systolic heart failure; adipose tissue; aged; body mass; factual database; heart ventricle; heart ventricle tachycardia; middle aged; mortality; nuclear magnetic resonance imaging; obesity; pathology; pathophysiology; pericardium; risk factor; systolic heart failure; treatment outcome; Adipose Tissue; Adiposity; Aged; Body Mass Index; Databases, Factual; Female; Follow-Up Studies; Heart Failure, Systolic; Heart Ventricles; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pericardium; Prognosis; Retrospective Studies; Risk Factors; Tachycardia, Ventricular; Treatment Outcome; Ventricular Fibrillation |
顯示於: | 醫療器材與醫學影像研究所 |
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