https://scholars.lib.ntu.edu.tw/handle/123456789/468740
標題: | Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia | 作者: | Yu R. MING-HSIEN HSIEH Wang H.-L.S. CHIH-MIN LIU CHEN-CHUNG LIU TZUNG-JENG HWANG YI-LING CHIEN Hwu H.-G. WEN-YIH TSENG |
公開日期: | 2013 | 卷: | 8 | 期: | 3 | 來源出版物: | PLoS ONE | 摘要: | Low frequency oscillations are essential in cognitive function impairment in schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific frequency bands. Here, we used a regional homogeneity (ReHo) method combined with resting-state functional magnetic resonance imaging to investigate low frequency spontaneous neural activity in the three different frequency bands (slow-5:0.01-0.027 Hz; slow-4:0.027-0.08 Hz; and typical band: 0.01-0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. Compared with controls, schizophrenia patients exhibited decreased ReHo in the precentral gyrus, middle occipital gyrus, and posterior insula, whereas increased ReHo in the medial prefrontal cortex and anterior insula. Significant differences in ReHo between the two bands were found in fusiform gyrus and superior frontal gyrus (slow-4> slow-5), and in basal ganglia, parahippocampus, and dorsal middle prefrontal gyrus (slow-5> slow-4). Importantly, we identified significant interaction between frequency bands and groups in the inferior occipital gyrus and caudate body. This study demonstrates that ReHo changes in schizophrenia are widespread and frequency dependent. ? 2013 Yu et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874593561&doi=10.1371%2fjournal.pone.0057516&partnerID=40&md5=9e78248519308c4ce1d0f4f598734683 https://scholars.lib.ntu.edu.tw/handle/123456789/468740 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0057516 | SDG/關鍵字: | adult; anterior insula; article; basal ganglion; brain region; controlled study; electroencephalogram; female; fusiform gyrus; human; major clinical study; male; middle frontal gyrus; nerve cell; occipital gyrus; parahippocampal gyrus; posterior insula; prefrontal cortex; primary motor cortex; schizophrenia; sensorimotor function; superior frontal gyrus; Adult; Brain; Brain Mapping; Case-Control Studies; Demography; Female; Humans; Male; Schizophrenia |
顯示於: | 醫療器材與醫學影像研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。