https://scholars.lib.ntu.edu.tw/handle/123456789/468816
標題: | Angiogenic response of locally advanced breast cancer to neoadjuvant chemotherapy evaluated with parametric histogram from dynamic contrast-enhanced MRI | 作者: | YEUN-CHUNG CHANG CHIUN-SHENG HUANG Liu Y.-J. Chen J.-H. YEN-SHEN LU WEN-YIH TSENG |
公開日期: | 2004 | 卷: | 49 | 期: | 16 | 起(迄)頁: | 3593-3602 | 來源出版物: | Physics in Medicine and Biology | 摘要: | The aim of this study was to evaluate angiogenic compositions and tumour response in the course of neoadjuvant chemotherapy in patients with locally advanced breast cancer (LABC) using dynamic contrast-enhanced (DCE) MRI. Thirteen patients with LABC underwent serial DCE MRI during the course of chemotherapy. DCE MRI was quantified using a two-compartment model on a pixel-by-pixel basis. Analysis of parametric histograms of amplitude, exchange rate kout and peak enhancement over the whole tumour was performed. The distribution patterns of histograms were correlated with the tumour response. Initial kurtosis and standard deviation of amplitude before chemotherapy correlated with tumour response, r = 0.63 and r = 0.61, respectively. Comparing the initial values with the values after the first course of chemotherapy, tumour response was associated with a decrease in standard deviation of amplitude (r = 0.79), and an increase in kurtosis and a decrease in standard deviation of kout (r = 0.57 and 0.57, respectively). Comparing the initial values with the values after completing the chemotherapy, tumours with better response were associated with an increase in kurtosis (r = 0.62), a decrease in mean (r = 0.84) and standard deviation (r = 0.77) of amplitude, and a decrease in mean of peak enhancement (r = 0.7 1). Our results suggested that tumours with better response tended to alter their internal compositions from heterogeneous to homogeneous distributions and a decrease in peak enhancement after chemotherapy. Serial analyses of parametric histograms of DCE MRI-derived angiogenic parameters are potentially useful to monitor the response of angiogenic compositions of a tumour throughout the course of chemotherapy, and might predict tumour response early in the course. ? 2004 IOP Publishing Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4444242790&doi=10.1088%2f0031-9155%2f49%2f16%2f007&partnerID=40&md5=1343db7937600ec3d9ec61638ec6dfc0 https://scholars.lib.ntu.edu.tw/handle/123456789/468816 |
ISSN: | 0031-9155 | DOI: | 10.1088/0031-9155/49/16/007 | SDG/關鍵字: | Chemotherapy; Oncology; Patient monitoring; Tumors; Angiogenic response; Locally advanced breast cancer (LABC); Magnetic resonance imaging; antineoplastic agent; cisplatin; cyclophosphamide; docetaxel; doxorubicin; epirubicin; fluorouracil; folinic acid; gadolinium pentetate; navelbine; paclitaxel; UFT; adjuvant chemotherapy; adult; advanced cancer; amplitude modulation; analytical parameters; article; breast cancer; clinical article; comparative study; contrast enhancement; controlled study; correlation analysis; diagnostic value; dynamics; histogram; human; mathematical model; nuclear magnetic resonance imaging; parametric test; priority journal; Adult; Biopsy; Breast Neoplasms; Chemotherapy, Adjuvant; Contrast Media; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Middle Aged; Neovascularization, Pathologic; Time Factors |
顯示於: | 醫療器材與醫學影像研究所 |
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