Clinicopathologic features and treatment outcome of non-Hodgkin lymphoma of the breast - A review of 42 primary and secondary cases in Taiwanese patients
Journal
Leukemia and Lymphoma
Journal Volume
50
Journal Issue
6
Pages
918-924
Date Issued
2009
Author(s)
Abstract
Breast lymphoma is a rare form of non-Hodgkin lymphoma (NHL). However, its clinicopathologic features, treatment, patterns of failure and prognosis remains unclear. We reviewed the clinicopathologic features, treatment variables, failure patterns and the clinical outcome of all cases of breast NHL diagnosed in three institutions in Taiwan between 1984 and 2006. The diagnosis, based on the criteria proposed by Wiseman and Liao, was primary breast lymphoma (PBL) in 23 patients and secondary breast lymphoma (SBL) in 19. Diffuse large B-cell lymphoma was the predominant histological type of both. Among patients with PBL, 18 received chemotherapy and radiotherapy, 3 received chemotherapy alone and 2 received radiotherapy alone. In contrast, all 19 patients with SBL received chemotherapy alone. At a median follow-up of 4.4 years, patients with PBL had a significantly better 5-year event-free survival and overall survival. The contralateral breast was the predominant site of recurrence for patients with PBL. In multivariate analyses, young age and stage IIE disease were significantly associated with poorer prognosis of PBL. Our results indicate combined modality treatment results in a favourable outcome for patients with PBL. Further investigation of underlying mechanisms of young age- and stage IIE disease-related poor prognosis in patients with PBL is needed.
Other Subjects
antineoplastic agent; rituximab; adult; age; article; cancer chemotherapy; cancer radiotherapy; cancer recurrence; cancer staging; cancer survival; clinical article; event free survival; female; follicular lymphoma; human; large cell lymphoma; mastectomy; mucosa associated lymphoid tissue lymphoma; nonhodgkin lymphoma; overall survival; pimary breast lymphoma; primary breast lymphoma; primary tumor; priority journal; prognosis; second cancer; secondary breast lymphoma; survival time; Adult; Age Factors; Aged; Aged, 80 and over; Breast Neoplasms; Combined Modality Therapy; Drug Therapy; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prognosis; Radiotherapy; Survival Analysis; Taiwan; Treatment Outcome; Young Adult
Type
journal article