Loss of CD7, independent of galectin-3 expression, implies a worse prognosis in adult T-cell leukaemia/lymphoma
Journal
Histopathology
Journal Volume
54
Journal Issue
2
Pages
214-220
Date Issued
2009
Author(s)
Abstract
Aims: Loss of CD7 is characteristic of adult T-cell lymphoma/leukaemia (ATLL). Galectin-3 (Gal-3) is strongly induced in cultured human T lymphotropic virus-1-infected T lymphocytes, and may cause apoptosis through interaction with CD7. The aim was to investigate the clinical relevance of the Gal-3-CD7 pathway in ATLL. Methods and results: Immunohistochemistry for Gal-3 and CD7 was performed on 22 cases of ATLL in the leukaemic phase. We found that the lymphoma cells were not necessarily Gal-3+, but Gal-3+ stromal cells could always be found. Independent of the status of Gal-3, there was an association of loss of CD7 with a worse prognosis. Conclusions: These data suggest that, by down-regulating CD7, ATLL cells could have escaped Gal-3-induced apoptosis to run a more aggressive clinical course. ? 2008 Blackwell Publishing Limited.
SDGs
Other Subjects
CD7 antigen; galectin 3; acute disease; adult; aged; article; chromosome 9p; chronic disease; controlled study; ethnic difference; female; human; human tissue; immunohistochemistry; major clinical study; male; priority journal; prognosis; protein expression; stroma cell; T cell leukemia; Adult; Aged; Antigens, CD7; Apoptosis; Cells, Cultured; Chromosome Aberrations; Down-Regulation; Female; Galectin 3; Humans; Immunohistochemistry; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Prognosis; Human T-lymphotropic virus 1
Type
journal article