Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Pathology / 病理學科所
  4. Presence of restricted killer immunoglobulin-like receptor repertoire and monoclonal T-cell receptor γ rearrangement as evidence of mixed NK/T-cell differentiation in a subset of sinonasal lymphomas
 
  • Details

Presence of restricted killer immunoglobulin-like receptor repertoire and monoclonal T-cell receptor γ rearrangement as evidence of mixed NK/T-cell differentiation in a subset of sinonasal lymphomas

Journal
Laboratory Investigation
Journal Volume
83
Journal Issue
1
Pages
55-64
Date Issued
2003
Author(s)
CHUNG-WU LIN  
Yang J.-Y.
Chuang Y.-C.
Chen Y.-H.
Albitar M.
Hsu S.-M.
DOI
10.1097/01.LAB.0000047491.62596.A3
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037239403&doi=10.1097%2f01.LAB.0000047491.62596.A3&partnerID=40&md5=7d0e2ce095a26ef3ee183a6b088711b1
https://scholars.lib.ntu.edu.tw/handle/123456789/468910
Abstract
Most sinonasal lymphomas have a restricted killer immunoglobulin-like receptor (KIR) repertoire without a monoclonal T-cell receptor-γ (TCR-γ) rearrangement, implying an NK lineage. However, the lineage assignment of sinonasal lymphoma with a monoclonal TCR-γ rearrangement is unclear because of its mixed NK/T phenotype. The possibility of a mixed NK/T lineage arises with the discovery of T cells with NK features, such as KIR+ T cells or Vα24+ NKT cells. The former might transform into a T-cell lymphoma with both a monoclonal TCR-γ rearrangement and a restricted KIR repertoire; the latter might give rise to a T-cell lymphoma with a monoclonal Vα24 rearrangement and possibly a restricted KIR repertoire. To identify such mixed-lineage lymphomas, we undertook a survey of 15 consecutive sinonasal lymphomas and found six with both a restricted KIR repertoire and a monoclonal TCR-γ rearrangement, consistent with KIR+ T-cell lymphomas. Among these six cases, four female CD56-/CD44-/CD8-/CD45RO+/ CD45RA- cases constituted a distinct group with a better prognosis than the rest of the male cases of sinonasal lymphomas. None of the six cases had a monoclonal Vα24 repertoire, thus excluding a derivation from NKT cells. The predominance of KIR+ T cells that normally function in chronic viral infections over Vα24+ NKT cells that typically recognize glycolipid antigens is consistent with the known association of Epstein-Barr virus infection with sinonasal lymphoma. The demonstration of mixed lineage in a mature lymphoid neoplasm is unusual and echoes the World Health Organization classification that placed NK-cell and T-cell lymphomas in a mixed group.
SDGs

[SDGs]SDG3

Other Subjects
CD45 antigen; CD56 antigen; CD8 antigen; Hermes antigen; immunoglobulin receptor; protein subunit; T lymphocyte receptor gamma chain; adolescent; adult; aged; antigen binding; article; cellular immunity; clinical article; clinical feature; controlled study; disease association; Epstein Barr virus; female; gene rearrangement; genetic linkage; health survey; human; immunopathology; lymphocyte differentiation; lymphoma; male; mixed cell culture; natural killer cell; nose tumor; paranasal sinus tumor; phenotype; priority journal; prognosis; protein expression; receptor gene; virus infection; world health organization
Publisher
Lippincott Williams and Wilkins
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science