https://scholars.lib.ntu.edu.tw/handle/123456789/468910
標題: | Presence of restricted killer immunoglobulin-like receptor repertoire and monoclonal T-cell receptor γ rearrangement as evidence of mixed NK/T-cell differentiation in a subset of sinonasal lymphomas | 作者: | CHUNG-WU LIN Yang J.-Y. Chuang Y.-C. Chen Y.-H. Albitar M. Hsu S.-M. |
公開日期: | 2003 | 出版社: | Lippincott Williams and Wilkins | 卷: | 83 | 期: | 1 | 起(迄)頁: | 55-64 | 來源出版物: | Laboratory Investigation | 摘要: | Most sinonasal lymphomas have a restricted killer immunoglobulin-like receptor (KIR) repertoire without a monoclonal T-cell receptor-γ (TCR-γ) rearrangement, implying an NK lineage. However, the lineage assignment of sinonasal lymphoma with a monoclonal TCR-γ rearrangement is unclear because of its mixed NK/T phenotype. The possibility of a mixed NK/T lineage arises with the discovery of T cells with NK features, such as KIR+ T cells or Vα24+ NKT cells. The former might transform into a T-cell lymphoma with both a monoclonal TCR-γ rearrangement and a restricted KIR repertoire; the latter might give rise to a T-cell lymphoma with a monoclonal Vα24 rearrangement and possibly a restricted KIR repertoire. To identify such mixed-lineage lymphomas, we undertook a survey of 15 consecutive sinonasal lymphomas and found six with both a restricted KIR repertoire and a monoclonal TCR-γ rearrangement, consistent with KIR+ T-cell lymphomas. Among these six cases, four female CD56-/CD44-/CD8-/CD45RO+/ CD45RA- cases constituted a distinct group with a better prognosis than the rest of the male cases of sinonasal lymphomas. None of the six cases had a monoclonal Vα24 repertoire, thus excluding a derivation from NKT cells. The predominance of KIR+ T cells that normally function in chronic viral infections over Vα24+ NKT cells that typically recognize glycolipid antigens is consistent with the known association of Epstein-Barr virus infection with sinonasal lymphoma. The demonstration of mixed lineage in a mature lymphoid neoplasm is unusual and echoes the World Health Organization classification that placed NK-cell and T-cell lymphomas in a mixed group. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037239403&doi=10.1097%2f01.LAB.0000047491.62596.A3&partnerID=40&md5=7d0e2ce095a26ef3ee183a6b088711b1 https://scholars.lib.ntu.edu.tw/handle/123456789/468910 |
ISSN: | 0023-6837 | DOI: | 10.1097/01.LAB.0000047491.62596.A3 | SDG/關鍵字: | CD45 antigen; CD56 antigen; CD8 antigen; Hermes antigen; immunoglobulin receptor; protein subunit; T lymphocyte receptor gamma chain; adolescent; adult; aged; antigen binding; article; cellular immunity; clinical article; clinical feature; controlled study; disease association; Epstein Barr virus; female; gene rearrangement; genetic linkage; health survey; human; immunopathology; lymphocyte differentiation; lymphoma; male; mixed cell culture; natural killer cell; nose tumor; paranasal sinus tumor; phenotype; priority journal; prognosis; protein expression; receptor gene; virus infection; world health organization |
顯示於: | 病理學科所 |
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