https://scholars.lib.ntu.edu.tw/handle/123456789/468911
標題: | Spontaneous regression of Kikuchi lymphadenopathy with oligoclonal T-cell populations favors a benign immune reaction over a T-cell lymphoma | 作者: | CHUNG-WU LIN Chang C.-L. Li C.-C. Chen Y.-H. Lee W.-H. Hsu S.-M. |
公開日期: | 2002 | 卷: | 117 | 期: | 4 | 起(迄)頁: | 627-635 | 來源出版物: | American Journal of Clinical Pathology | 摘要: | To aid in the initial diagnosis of Kikuchi lymphadenitis and to assess whether the composition of the T cells might shed light on the pathogenesis, we used nested polymerase chain reaction tests followed by high-resolution gel electrophoresis to determine the pattern of T-cell antigen receptor rearrangement in 56 consecutive cases. Except for 1 unusual case with recurrent lymphadenopathy, none had a monoclonal beta or gamma rearrangement. Eight cases had a polyclonal pattern at both beta and gamma loci, 20 cases had a mixed polyclonal beta and oligoclonal gamma pattern, and 27 cases had an oligoclonal pattern at both loci. The high frequency of oligoclonality did not indicate an early-stage T-cell lymphoma in evolution, as confirmed by spontaneous resolution of the lymphadenopathy in all cases within 6 months. Rather, it is consistent with reports of oligoclonal T cells in a variety of immune reactions. We conclude that, in the vast majority of cases, absence of a monoclonal T-cell receptor rearrangement excludes the possibility of T-cell lymphoma, and the presence of an oligoclonal pattern implies a benign immune reaction. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036320348&doi=10.1309%2fD4BH-G1WU-0UB0-U9JD&partnerID=40&md5=cf2a2bae26f217995d45256d1496dc9d https://scholars.lib.ntu.edu.tw/handle/123456789/468911 |
ISSN: | 0002-9173 | DOI: | 10.1309/D4BH-G1WU-0UB0-U9JD | SDG/關鍵字: | T lymphocyte receptor; T lymphocyte receptor beta chain; T lymphocyte receptor gamma chain; article; clonogenesis; controlled study; gene rearrangement; histopathology; human; human tissue; immunopathogenesis; Kikuchi disease; major clinical study; polymerase chain reaction; priority journal; T cell lymphoma; T lymphocyte; T lymphocyte receptor gene; Adolescent; Adult; Child; DNA Primers; Electrophoresis; Female; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Gene Rearrangement, T-Lymphocyte; Histiocytic Necrotizing Lymphadenitis; Humans; Lymphoma, T-Cell; Male; Middle Aged; Polymerase Chain Reaction |
顯示於: | 病理學科所 |
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