The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease
Journal
Scientific Reports
Journal Volume
8
Journal Issue
1
Date Issued
2018
Author(s)
Ho S.-K.
Tseng W.-K.
Leu H.-B.
Yin W.-H.
Lin T.-H.
Chang K.-C.
Wang J.-H.
Yeh H.-I.
Chen J.-W.
Abstract
To investigate the prognostic value of heart-type fatty acid binding protein (H-FABP) in patients with stable coronary heart disease (SCHD). A total of 1,071 patients with SCHD were prospectively enrolled in this Taiwan multicenter registry study, followed for 24 months. The cut-off value of H-FABP, 4.143 pg/mL, was determined using receiver operating characteristic curves. The primary cardiovascular (CV) outcome was composite CV events, defined as cardiovascular or cerebrovascular death, myocardial infarction (MI), stroke, angina related-hospitalization, PAOD-related hospitalization and heart failure. Secondary outcomes included CV or cerebrovascular death, nonfatal MI, nonfatal stroke, and acute heart failure-related hospitalization. We found that the high H-FABP group had more than a two-fold higher rate of primary CV outcomes than the low H-FABP group (32.36% vs. 15.78%, p < 0.001). Eleven patients (4.82%) of the high H-FABP group died during the 24 months of follow-up, compared to only one patient (0.12%) in the low H-FABP group. The acute heart failure-related hospitalization rate was also significantly higher in the high H-FABP group (3.5% vs. 0.95%, p < 0.005). The results remained significant after adjusting for baseline covariates. In conclusion, H-FABP was an independent predictor for CV outcomes in the patients with SCHD, mainly in CV death and acute heart failure-related hospitalization. ? 2018, The Author(s).
SDGs
Other Subjects
fatty acid binding protein 3; adult; blood; clinical trial; coronary artery disease; female; follow up; human; Kaplan Meier method; male; multicenter study; prognosis; prospective study; Taiwan; young adult; Adult; Coronary Disease; Fatty Acid Binding Protein 3; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Prognosis; Prospective Studies; Taiwan; Young Adult
Publisher
Nature Publishing Group
Type
journal article