https://scholars.lib.ntu.edu.tw/handle/123456789/470337
標題: | Traditional serrated adenoma with BRAF mutation is associated with synchronous/metachronous BRAF-mutated serrated lesions | 作者: | JIA-HUEI TSAI Cheng C.-H. CHIEN-CHUAN CHEN Lin Y.-L. LIANG-IN LIN Chen M.-L. JAU-YU LIAU |
公開日期: | 2016 | 出版社: | Blackwell Publishing Ltd | 卷: | 68 | 期: | 6 | 起(迄)頁: | 810-818 | 來源出版物: | Histopathology | 摘要: | Aims: To determine whether traditional serrated adenoma (TSA) results in an increased risk of developing subsequent serrated polyps or colorectal cancer (CRC). Methods and results: We recruited 111 patients with an index TSA, and analysed the pathological and molecular features of their synchronous/metachronous serrated lesions. Fifty hyperplastic polyps, 14 sessile serrated adenomas, an additional 27 TSAs and 17 CRCs were identified from 46 patients. Twenty-seven percent of TSAs showed a precursor serrated polyp in the periphery and were strongly correlated with BRAF mutation (P < 0.001). Serrated polyps occurred more commonly in patients with BRAF-mutated index TSAs than in patients with KRAS-mutated index TSAs. BRAF-mutated index TSAs were strongly associated with a right-sided location and BRAF mutation of synchronous/metachronous serrated polyps (P = 0.013 and P = 0.005, respectively). The 17 CRCs occurred more frequently in women, and were characterized by a high BRAF mutation rate (59%), a positive CpG island methylator phenotype (59%), and stable or low levels of microsatellite instability (77%). Conclusions: BRAF-mutated TSA is distinct from KRAS-mutated TSA in predisposing to the acquisition of subsequent serrated neoplasia. This indicates the presence of an intestinal field defect in the tumour microenvironment that results in tumour initiation and malignant progression. ? 2016 John Wiley & Sons Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949670180&doi=10.1111%2fhis.12814&partnerID=40&md5=9c97c1173b47a5cd27f91f47254cc474 https://scholars.lib.ntu.edu.tw/handle/123456789/470337 |
ISSN: | 0309-0167 | DOI: | 10.1111/his.12814 | SDG/關鍵字: | B Raf kinase; K ras protein; mismatch repair protein; B Raf kinase; BRAF protein, human; KRAS protein, human; protein p21; adult; aged; Article; clinical feature; controlled study; CpG island; female; gene mutation; genetic association; human; human tissue; major clinical study; male; microsatellite instability; oncogene K ras; phenotype; priority journal; randomized controlled trial; rectum adenoma; traditional serrated adenoma; tumor microenvironment; very elderly; adenoma; colon polyp; colorectal tumor; disease course; DNA microarray; dna mutational analysis; genetics; immunohistochemistry; middle aged; pathology; precancer; Adenoma; Adult; Aged; Colonic Polyps; Colorectal Neoplasms; Disease Progression; DNA Mutational Analysis; Female; Humans; Immunohistochemistry; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras) |
顯示於: | 病理學科所 |
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