Histologic evolution from adenocarcinoma to squamous cell carcinoma after gefitinib treatment
Journal
Annals of Thoracic Surgery
Journal Volume
99
Journal Issue
1
Pages
316-319
Date Issued
2015
Author(s)
Abstract
We report two cases of lung cancer with histologic transformation from adenocarcinoma to squamous cell carcinoma after gefitinib treatment. Both cases involved advanced lung cancers, initially confirmed as adenocarcinomas with sensitive epidermal growth factor gene mutations. After gefitinib treatment, the second pathologic examination in each case revealed squamous cell carcinoma retaining identical mutations without newly acquired resistance mutations. The underlying mechanism may have been pluripotent tumor cells with divergent differentiation or mixed lung cancer including both adenocarcinomatous and squamous cell carcinomatous components. This report widens the spectrum of histologic evolution as a mechanism underlying the acquisition of drug resistance. ? 2015 The Society of Thoracic Surgeons.
SDGs
Other Subjects
cisplatin; epidermal growth factor; erlotinib; gefitinib; gemcitabine; pemetrexed; platinum; protein p40; thyroid transcription factor 1; transcription factor; antineoplastic agent; gefitinib; quinazoline derivative; adult; Article; cancer combination chemotherapy; case report; computer assisted tomography; coughing; exon; female; follow up; gene mutation; genetic resistance; histopathology; human; human cell; human tissue; immunohistochemistry; immunoreactivity; Klebsiella pneumoniae; lobectomy; lung adenocarcinoma; lung biopsy; lymph node dissection; malignant transformation; middle aged; pleura effusion; pleura metastasis; point mutation; priority journal; squamous cell; squamous cell lung carcinoma; treatment response; tumor cell; video assisted thoracoscopic surgery; adenocarcinoma; cell transformation; chemically induced; Lung Neoplasms; pathology; squamous cell carcinoma; Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female; Humans; Lung Neoplasms; Middle Aged; Quinazolines
Publisher
Elsevier USA
Type
journal article