|Title:||Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway||Authors:||Chang J.-W.
|Issue Date:||2018||Publisher:||Nature Publishing Group||Journal Volume:||37||Journal Issue:||30||Start page/Pages:||4137-4150||Source:||Oncogene||Abstract:||
The early onset breast cancer patients (age ? 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecules associated with poor prognosis of early onset breast cancer, we examined gene expression profiles from paired breast normal/tumor tissues, and coupled with Gene Ontology and public data base analysis. Our data showed that the expression of GAS7b gene was lower in the early onset breast cancer patients as compared to the elder patients. We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and β1-integrin/FAK/Src signaling. We further demonstrated that p53 directly regulated GAS7 gene expression, which was inversely correlated with p53 mutations in breast cancer specimens. Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7–CYFIP1-mediated signaling pathways. ? 2018, The Author(s).
|ISSN:||0950-9232||DOI:||10.1038/s41388-018-0253-9||SDG/Keyword:||beta1 integrin; protein p53; Rac1 protein; beta1 integrin; CYFIP1 protein, human; focal adhesion kinase 1; GAS7 protein, human; nerve protein; protein kinase p60; protein p53; signal transducing adaptor protein; TP53 protein, human; Wiskott Aldrich syndrome protein; actin polymerization; adult; animal experiment; animal tissue; Article; axillary lymph node; breast cancer; cancer incidence; cancer patient; cancer prognosis; cancer survival; controlled study; GAS7b gene; gene; gene expression; gene ontology; human; human tissue; lymph node metastasis; metastasis; mouse; nonhuman; priority journal; protein binding; protein protein interaction; signal transduction; upregulation; wild type; animal; breast tumor; female; gene expression regulation; genetics; MCF-7 cell line; pathology; tumor cell line; Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Line, Tumor; Female; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Humans; Integrin beta1; Lymphatic Metastasis; MCF-7 Cells; Mice; Nerve Tissue Proteins; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Tumor Suppressor Protein p53; Up-Regulation; Wiskott-Aldrich Syndrome Protein Family
|Appears in Collections:||病理學科所|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.